Genomic Epidemiology and Lineage Dynamics of SARS-CoV-2 in Bulgaria: Insights from a Three-Year Pandemic Analysis

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought about significant challenges worldwide. In this study, we present a comprehensive analysis of the genomic epidemiology and lineage dynamics of SARS-CoV-2 in Bulgaria over a three-year period. Thr...

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Bibliographic Details
Published in:Viruses 2023-09, Vol.15 (9), p.1924
Main Authors: Giovanetti, Marta, Cella, Eleonora, Ivanov, Ivan, Grigorova, Lyubomira, Stoikov, Ivan, Donchev, Deyan, Dimitrova, Reneta, Slavov, Svetoslav Nanev, Mavian, Carla, Fonseca, Vagner, Scarpa, Fabio, Borsetti, Alessandra, Korsun, Neli, Trifonova, Ivelina, Dobrinov, Veselin, Kantardjiev, Todor, Christova, Iva, Ciccozzi, Massimo, Alexiev, Ivailo
Format: Article
Language:English
Subjects:
Bulgaria
Coronaviruses
COVID-19
COVID-19 vaccines
Datasets
Disease transmission
Epidemics
Epidemiology
Genetic aspects
Genomes
Genomic analysis
genomic surveillance
Immunization
Maximum likelihood method
Metadata
Morbidity
Mortality
Mutation
Natural history
Pandemics
Phylogenetics
Public health
Quarantine
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Spatial distribution
Vaccination
viral evolution
Virus research
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Summary:The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought about significant challenges worldwide. In this study, we present a comprehensive analysis of the genomic epidemiology and lineage dynamics of SARS-CoV-2 in Bulgaria over a three-year period. Through extensive genomic sequencing and data analysis, we investigated the evolution of the virus, the emergence of variants of concern (VOCs), and their impact on the country’s pandemic trajectory. We also assessed the relationship between viral diversity and COVID-19 morbidity and mortality in Bulgaria. Our findings shed light on the temporal and spatial distribution of SARS-CoV-2 lineages and provide crucial insights into the dynamics of the pandemic in the country. The interplay between international travel and viral transmission plays a significant role in the emergence and dissemination of different SARS-CoV-2 variants. The observed proportions of exportation to various continents provide insights into the potential pathways through which these lineages spread globally. Understanding the genomic epidemiology of SARS-CoV-2 in Bulgaria is essential for formulating targeted public health strategies, enhancing vaccination efforts, and effectively managing future outbreaks.
ISSN:1999-4915
1999-4915
DOI:10.3390/v15091924