Evaluation of CAT Variants A-89T, C389T, and C419T in Patients with Vitiligo in the Saudi Population

: Vitiligo is a chronic autoimmune and depigmentation disorder in humans that manifests as whitening lesions. Reactive oxygen species (ROS) are involved in cell damage. Catalase (CAT) is a well-known oxidative stress regulator and is primarily responsible for the catalytic decomposition of hydrogen...

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Published in:Medicina (Kaunas, Lithuania) Lithuania), 2023-04, Vol.59 (4), p.708
Main Authors: Saif, Ghada A Bin, Alshammary, Amal F, Ali Khan, Imran
Format: Article
Language:English
Subjects:
A-89T
Age
Autoimmune diseases
C389T
C419T
Case-Control Studies
CAT gene
Catalase - genetics
Consent
Disease
Enzymes
Family medical history
Genes
Genetic Predisposition to Disease - genetics
Genotype
Humans
Immune system
Immunology
Mutation
Oxidative stress
Reactive oxygen species
Saudi Arabia - epidemiology
Skin
Vitiligo
Vitiligo - epidemiology
Vitiligo - genetics
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Summary:: Vitiligo is a chronic autoimmune and depigmentation disorder in humans that manifests as whitening lesions. Reactive oxygen species (ROS) are involved in cell damage. Catalase (CAT) is a well-known oxidative stress regulator and is primarily responsible for the catalytic decomposition of hydrogen peroxide into water and oxygen. Based on previous case-control and meta-analysis studies, we assessed the prevalence of three single-nucleotide polymorphisms (SNPs) of the genes A-89T (rs7943316), C389T (rs769217) and C419T (rs11032709) in participants with vitiligo and healthy controls in the Saudi population. : We recruited 152 participants with vitiligo and 159 healthy controls for A-89T, C389T, and C419T SNP genotyping studies using PCR and RFLP analysis. Additionally, we performed linkage disequilibrium and haplotype analyses between vitiligo cases and controls. : The rs7943316 and rs11032709 SNPs of the genes showed a positive association with vitiligo for both heterozygous genotypes and dominant genetic models (TT + AT vs. AA in A-89T and TT + CT vs. CC in C389T), in the gene. Linkage disequilibrium analysis revealed a moderate linkage between rs7943316 and rs11032709 SNPs in vitiligo cases and controls. Haplotype frequency estimation revealed a significant association ( = 0.003) among the three SNP alleles. : The rs7943316 and rs11032709 SNPs of the genes were strongly associated with susceptibility to vitiligo.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina59040708