Investigation of the pharmacological characteristics of Sphaeranthus indicus flowers using phytochemical analysis

Although the conventional usage of Sphaeranthus indicus flowers in medicine exists, there is a lack of research on the precise pharmacological characteristics and comprehensive phytochemical composition of its flowers, resulting in a knowledge gap on their whole therapeutic capabilities. The aim of...

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Bibliographic Details
Published in:Journal of advanced biotechnology and experimental therapeutics 2024-03, Vol.7 (3), p.642-657
Main Authors: khanam, Afsana, Roman, Tahamina, Ferdous, Afsana, Siddique, Mohammed, Antu, Nadia, Arman, Mohammad, Islam, Mohammad
Format: Article
Language:English
Subjects:
anti-inflammatory
antidepressants
antidiarrheal
antimicrobial
antioxidants
sphaeranthus indicus
thrombolytic
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Summary:Although the conventional usage of Sphaeranthus indicus flowers in medicine exists, there is a lack of research on the precise pharmacological characteristics and comprehensive phytochemical composition of its flowers, resulting in a knowledge gap on their whole therapeutic capabilities. The aim of this work is to identify and describe the phytochemicals found in the flowers of Sphaeranthus indicus and assess specific pharmacological effects, such as antioxidant, antibacterial, anti-inflammatory, thrombolytic, antidepressant, and antidiarrheal characteristics. The investigation revealed that the MESIF (methanol extract of S. indicus flowers) showed substantial antioxidant performance (IC50 = 26.33) accompanied by a moderate phenolic content (93.33 ± 1.76). At 250 and 500 µg/ml, the extract exhibited modest to moderate antibacterial sensitivity against many tested pathogens and significantly reduced inflammation by protein denaturation (41.63 ± 0.11 and 70.52 ± 0.20). Furthermore, MESIF exhibited remarkable thrombolytic activity with a statistically significant (***P
ISSN:2616-4760
2616-4760
DOI:10.5455/jabet.2024.d55