Action mechanism and cardiovascular effect of anthocyanins: a systematic review of animal and human studies

Cardiovascular diseases (CVD) are an important cause of death worldwide. Anthocyanins are a subgroup of flavonoids found in berries, flowers, fruits and leaves. In epidemiological and clinical studies, these polyphenols have been associated with improved cardiovascular risk profiles as well as decre...

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Bibliographic Details
Published in:Journal of translational medicine 2016-11, Vol.14 (1), p.315-315, Article 315
Main Authors: Reis, Jordano Ferreira, Monteiro, Valter Vinicius Silva, de Souza Gomes, Rafaelli, do Carmo, Matheus Moraes, da Costa, Glauber Vilhena, Ribera, Paula Cardoso, Monteiro, Marta Chagas
Format: Article
Language:English
Subjects:
Analysis
Animal models
Animals
Anthocyanin
Anthocyanins
Anthocyanins - chemistry
Anthocyanins - pharmacology
Anthocyanins - therapeutic use
Antioxidants - pharmacology
Antioxidants - therapeutic use
Biomarkers - metabolism
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - drug therapy
Cardiovascular System - drug effects
Cardiovascular System - pathology
Disease Models, Animal
Epidemiology
Health aspects
Human study
Humans
Lipid peroxidation
Oxidative stress
Polyphenols
Review
Risk factors
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Summary:Cardiovascular diseases (CVD) are an important cause of death worldwide. Anthocyanins are a subgroup of flavonoids found in berries, flowers, fruits and leaves. In epidemiological and clinical studies, these polyphenols have been associated with improved cardiovascular risk profiles as well as decreased comorbidities. Human intervention studies using berries, vegetables, parts of plants and cereals (either fresh or as juice) or purified anthocyanin-rich extracts have demonstrated significant improvements in low density lipoproteins oxidation, lipid peroxidation, total plasma antioxidant capacity, and dyslipidemia as well as reduced levels of CVD molecular biomarkers. This review discusses the use of anthocyanins in animal models and their applications in human medicine, as dietary supplements or as new potent drugs against cardiovascular disease.
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-016-1076-5