Study of risk factor of urinary calculi according to the association between stone composition with urine component

• Published in: Scientific reports 2021-04, Vol.11 (1), p.8723-8723, Article 8723
• Main Authors: Wang, Pan, Zhang, Hongxian, Zhou, Jiansuo, Jin, Shangjia, Liu, Chong, Yang, Boxin, Cui, Liyan
• Format: Article
• Language: English
• Subjects: 692/499; 692/53/2423; Calcification (ectopic); Calcium; Calcium oxalate; Chemicals; Humanities and Social Sciences; Kidney stones; Lithiasis; Magnesium; multidisciplinary; Oxalic acid; Risk factors; Science; Science (multidisciplinary); Surgery; Urine
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-87733-7

Urolithiasis is a common urinary disease with high recurrence. The risk factor for the recurrence of calculi is not very clear. The object of the present study was to evaluate the association between calculi composition and urine component and analyse the risk factor for the recurrence of urolithiasis. In this study, a total of 223 patients with calculi and healthy control were enrolled, and the components of the calculi and urina sanguinis collected before surgery were analysed. Of the 223 patients, 157 were males and 66 were females. According to the stone composition, the case group was subdivided into three groups. 129 patients had single calcium oxalate stones, 72 had calcium oxalate stones mixed with other stones and 22 had other type of stones excluding calcium oxalate stones. Urine biochemicals were analysed and the associations were found between the chemicals in each group. Multivariate logistic analysis demonstrated that reduced urinary magnesium and uric oxalic acid were independent risk factors when comparing all cases with normal controls. Only decreased urinary magnesium was found to be a risk factor comparing the single calcium oxalate group with normal control group. Low level of urinary magnesium and uric oxalic acid were found to be risk factors comparing the mixed calcium oxalate group with normal control group. No risk factor was found comparing the other stone group with normal control group. In conclusion, there were clear relationships between stone components and urine chemicals. Urine chemicals might be risk factors to predicate the occurrence of urolithiasis.