New Insights into Blood Circulating Lymphocytes in Human Pneumocystis Pneumonia

The host lymphocyte response is decisive in Pneumocystis pneumonia (PCP) pathophysiology but little is known of the specific roles of lymphocyte subpopulations in this fungal infection. Peripheral NK, NKT, B, TCD4+ and TCD8+ subpopulations were compared by immunophenotyping between 20 patients diagn...

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Bibliographic Details
Published in:Journal of fungi (Basel) 2021-08, Vol.7 (8), p.652
Main Authors: Charpentier, Eléna, Marques, Catherine, Ménard, Sandie, Chauvin, Pamela, Guemas, Emilie, Cottrel, Claire, Cassaing, Sophie, Fillaux, Judith, Valentin, Alexis, Blanchard, Nicolas, Berry, Antoine, Iriart, Xavier
Format: Article
Language:English
Subjects:
B lymphocytes
Blood & organ donations
CD8 antigen
Cell number
Disease
Dyspnea
Experiments
Health care
HIV
Human health and pathology
Human immunodeficiency virus
Immunological memory
immunophenotyping
Infectious diseases
Life Sciences
lymphocyte
Lymphocytes
Lymphocytes B
Lymphocytes T
Medical prognosis
Pathophysiology
Patients
Pneumocystis jirovecii
pneumocystosis
Pneumonia
Software
Steroids
T helper
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Summary:The host lymphocyte response is decisive in Pneumocystis pneumonia (PCP) pathophysiology but little is known of the specific roles of lymphocyte subpopulations in this fungal infection. Peripheral NK, NKT, B, TCD4+ and TCD8+ subpopulations were compared by immunophenotyping between 20 patients diagnosed with PCP (PCP(+)] and 20 uninfected immunosuppressed patients (PCP(−)). Among PCP(+) subjects, the lymphocyte populations were also compared between surviving and deceased patients. Low B cell count (
ISSN:2309-608X
2309-608X
DOI:10.3390/jof7080652