Activity of Protein Kinase A in the Frontal Cortex in Schizophrenia

Schizophrenia is a serious cognitive disorder characterized by disruptions in neurotransmission, a process requiring the coordination of multiple kinase-mediated signaling events. Evidence suggests that the observed deficits in schizophrenia may be due to imbalances in kinase activity that propagate...

Full description

Saved in:
Bibliographic Details
Published in:Brain sciences 2024-01, Vol.14 (1), p.13
Main Authors: Sahay, Smita, Henkel, Nicholas Daniel, Vargas, Christina Flora-Anabelle, McCullumsmith, Robert Erne, O'Donovan, Sinead Marie
Format: Article
Language:English
Subjects:
Analysis
Antipsychotics
Brain
Cognition disorders
Cognitive ability
Correlation analysis
Cortex (cingulate)
Cortex (frontal)
Cyclic adenylic acid
Cyclic AMP
Dopamine
enzyme activity
Enzymes
frontal cortex
Intracellular signalling
Kinases
Mental disorders
Neurotransmission
Neurotransmitter receptors
Optimization
postmortem
Prefrontal cortex
Protein kinase A
Protein kinases
Proteins
Psychotropic drugs
Schizophrenia
Transcription factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Schizophrenia is a serious cognitive disorder characterized by disruptions in neurotransmission, a process requiring the coordination of multiple kinase-mediated signaling events. Evidence suggests that the observed deficits in schizophrenia may be due to imbalances in kinase activity that propagate through an intracellular signaling network. Specifically, 3'-5'-cyclic adenosine monophosphate (cAMP)-associated signaling pathways are coupled to the activation of neurotransmitter receptors and modulate cellular functions through the activation of protein kinase A (PKA), an enzyme whose function is altered in the frontal cortex in schizophrenia. In this study, we measured the activity of PKA in human postmortem anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) tissue from schizophrenia and age- and sex-matched control subjects. No significant differences in PKA activity were observed in male and female individuals in either brain region; however, correlation analyses indicated that PKA activity in the ACC may be influenced by tissue pH in all subjects and by age and tissue pH in females. Our data provide novel insights into the function of PKA in the ACC and DLPFC in schizophrenia.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci14010013