CD2 Immunobiology

The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that binds to LFA3, a cell surface protein expressed on e.g., antigen-presenting cells. CD2 has an important role in the formation and organization of the immunological synapse that is formed between T cells and anti...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2020, Vol.11, p.1090-1090
Main Authors: Binder, Christian, Cvetkovski, Filip, Sellberg, Felix, Berg, Stefan, Paternina Visbal, Horacio, Sachs, David H, Berglund, Erik, Berglund, David
Format: Article
Language:English
Subjects:
Alefacept
Animals
CD2
CD2 Antigens - immunology
CD58
costimulation
costimulation blockade
Humans
Immunological Synapses - immunology
Immunology
LFA-3 (lymphocyte functional antigen-3)
Lymphocyte Activation - immunology
Medicin och hälsovetenskap
siplizumab
T cell activation
T-Lymphocytes - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that binds to LFA3, a cell surface protein expressed on e.g., antigen-presenting cells. CD2 has an important role in the formation and organization of the immunological synapse that is formed between T cells and antigen-presenting cells upon cell-cell conjugation and associated intracellular signaling. CD2 expression is upregulated on memory T cells as well as activated T cells and plays an important role in activation of memory T cells despite the coexistence of several other costimulatory pathways. Anti-CD2 monoclonal antibodies have been shown to induce immune modulatory effects and clinical studies have proven the safety and efficacy of CD2-targeting biologics. Investigators have highlighted that the lack of attention to the CD2/LFA3 costimulatory pathway is a . Overall, CD2 is an attractive target for monoclonal antibodies intended for treatment of pathologies characterized by undesired T cell activation and offers an avenue to more selectively target memory T cells while favoring immune regulation.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.01090