Association of serum levels of inflammatory cytokines with retinopathy of prematurity in preterm infants

Retinopathy of prematurity (ROP) is a retinal vascular developmental disease associated with risks factors such as supplementary oxygen use or low birth weight/early gestational age. Multiple studies have reported associations between ROP and systemic inflammation. In this study, we investigated ser...

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Published in:Frontiers in pediatrics 2024-01, Vol.11, p.1195904-1195904
Main Authors: Ling, Xiao Chun, Huang, Pin-Hsuan, Chen, Hung-Chi, Hsueh, Yi-Jen, Lee, Chia-Wen, Lien, Reyin, Lee, Chien-Chung, Chu, Shih-Ming, Chen, Kuan-Jen, Hwang, Yih-Shiou, Lai, Chi-Chun, Chiang, Ming-Chou, Wu, Wei-Chi
Format: Article
Language:English
Subjects:
anti-VEGF
biomarker
cytokine
intravitreal injection
Pediatrics
retinopathy of prematurity
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Summary:Retinopathy of prematurity (ROP) is a retinal vascular developmental disease associated with risks factors such as supplementary oxygen use or low birth weight/early gestational age. Multiple studies have reported associations between ROP and systemic inflammation. In this study, we investigated serum cytokines associated with ROP development and severity and assessed their applicability as potential biomarkers of ROP. This prospective study was conducted at an institutional referral center between 2019 and 2021. To measure the serum levels of 40 inflammatory cytokines in eligible premature patients, we collected their serum samples during the enrollment of patients or the intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents and after 2 and 4 weeks. Fifty patients were enrolled. In patients with type 1 ROP who received anti-VEGF agents (  = 22), the levels of serum intercellular adhesion molecule-1 decreased significantly (  
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2023.1195904