Bioinformatics Analysis to Find Novel Biomarkers for Coronary Heart Disease

Background: Coronary heart disease (CHD), a major cause of death worldwide, is defined as a narrowing or blockage of the coronary arteries that supply oxygen and blood to the heart. We aimed to find potential biomarkers for coronary artery disease, by comparing the expression profile of blood exosom...

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Bibliographic Details
Published in:Iranian journal of public health 2022-05, Vol.51 (5), p.1152-1160
Main Authors: Gholipour, Akram, Shakerian, Farshad, Zahedmehr, Ali, Irani, Shiva, Malakootian, Mahshid, Mowla, Seyed Javad
Format: Article
Language:English
Subjects:
Arteries
Bioinformatics
Biomarkers
Blood
Blood exosomes
Cardiovascular disease
Cardiovascular diseases
Coronary artery
Coronary artery disease
Coronary heart disease
Data analysis
Datasets
Differentially expressed genes
Exosomes
Genes
Heart diseases
Immune system
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Summary:Background: Coronary heart disease (CHD), a major cause of death worldwide, is defined as a narrowing or blockage of the coronary arteries that supply oxygen and blood to the heart. We aimed to find potential biomarkers for coronary artery disease, by comparing the expression profile of blood exosomes of both normal and CHD samples. Methods: Datasets of 6 CHD and 6 normal samples of blood exosomes were downloaded, and differentially expressed RNAs, with adjusted P
ISSN:2251-6085
2251-6093
DOI:10.18502/ijph.v51i5.9430