Single-Molecule Surface-Enhanced Raman Spectroscopy

Single-molecule surface-enhanced Raman spectroscopy (SM-SERS) has the potential to detect single molecules in a non-invasive, label-free manner with high-throughput. SM-SERS can detect chemical information of single molecules without statistical averaging and has wide application in chemical analysi...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2022-06, Vol.22 (13), p.4889
Main Authors: Qiu, Yuxuan, Kuang, Cuifang, Liu, Xu, Tang, Longhua
Format: Article
Language:English
Subjects:
Analytical chemistry
Data analysis
Electric fields
Electromagnetism
Equipment and supplies
Literature reviews
Methods
Microscopy
Nanoelectronics
nanoparticle
Raman spectroscopy
Review
single-molecule detection
Spectrum analysis
Statistical analysis
surface plasmon resonance
Surface plasmon resonance sensors
surface-enhanced Raman spectroscopy
Testing
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Summary:Single-molecule surface-enhanced Raman spectroscopy (SM-SERS) has the potential to detect single molecules in a non-invasive, label-free manner with high-throughput. SM-SERS can detect chemical information of single molecules without statistical averaging and has wide application in chemical analysis, nanoelectronics, biochemical sensing, etc. Recently, a series of unprecedented advances have been realized in science and application by SM-SERS, which has attracted the interest of various fields. In this review, we first elucidate the key concepts of SM-SERS, including enhancement factor (EF), spectral fluctuation, and experimental evidence of single-molecule events. Next, we systematically discuss advanced implementations of SM-SERS, including substrates with ultra-high EF and reproducibility, strategies to improve the probability of molecules being localized in hotspots, and nonmetallic and hybrid substrates. Then, several examples for the application of SM-SERS are proposed, including catalysis, nanoelectronics, and sensing. Finally, we summarize the challenges and future of SM-SERS. We hope this literature review will inspire the interest of researchers in more fields.
ISSN:1424-8220
1424-8220
DOI:10.3390/s22134889