PEGylated Graphene Oxide Carried OH-CATH30 to Accelerate the Healing of Infected Skin Wounds

The treatment of ( )-infected wounds is difficult. It causes extreme pain to tens of thousands of patients and increases the cost of medical care. The antimicrobial peptide OH-CATH30 (OH30) has a good killing activity against and can play a role in accelerating wound healing and immune regulation. T...

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Bibliographic Details
Published in:International journal of nanomedicine 2021-01, Vol.16, p.4769-4780
Main Authors: Mei, Di, Guo, Xiaolong, Wang, Yirong, Huang, Xiaofei, Guo, Li, Zou, Pengfei, Ge, Delong, Wang, Xinxin, Lee, Wenhui, Sun, Tongyi, Gao, Zhiqin, Gao, Yuanyuan
Format: Article
Language:English
Subjects:
Analysis
Angiogenesis
Animals
Antibiotics
Bacteria
bacterial infection
Bacterial infections
Biocompatibility
Biological activity
Care and treatment
Casualties
Cytotoxicity
Drug resistance
Efficiency
Graphene
graphene oxide
Graphite
Health aspects
Humans
Infections
Medical care, Cost of
Mice
Microscopy
Moisture absorption
oh-cath30
Original Research
Peptides
Physiology
Polyethylene glycol
Polyethylene Glycols
Polyols
Potassium
Silicon wafers
Skin
skin wound
Spectrum analysis
Staphylococcus aureus
Staphylococcus aureus infections
Wound Healing
Wound Infection - drug therapy
Wounds and injuries
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Summary:The treatment of ( )-infected wounds is difficult. It causes extreme pain to tens of thousands of patients and increases the cost of medical care. The antimicrobial peptide OH-CATH30 (OH30) has a good killing activity against and can play a role in accelerating wound healing and immune regulation. Therefore, it shows great potential for wound healing. The aim of this study was to overcome the short half-life and easy enzymolysis of OH30 by using graphene oxide conjugated with polyethylene glycol to load OH30 (denoted as PGO-OH30), as well as to evaluate its effect on wounds infected by PGO-OH30 nanoparticles were prepared by π-π conjugation and characterized. Their cell cytotoxicity, cell migration, infectious full-thickness dermotomy models, and histopathology were evaluated. Characterization and cytotoxicity experiments revealed that the PGO-OH30 drug-delivery system had good biocompatibility and excellent drug-delivery ability. Cell-migration experiments showed that PGO-OH30 could promote the migration of human immortalized keratinocytes (HaCaT) cells compared with the control group (
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S304702