Extracellular Vesicles in Liver Transplantation: Current Evidence and Future Challenges

Extracellular vesicles (EVs) are emerging as a promising field of research in liver disease. EVs are small, membrane-bound vesicles that contain various bioactive molecules, such as proteins, lipids, and nucleic acids and are involved in intercellular communication. They have been implicated in nume...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-09, Vol.24 (17), p.13547
Main Authors: De Stefano, Nicola, Calleri, Alberto, Faini, Angelo Corso, Navarro-Tableros, Victor, Martini, Silvia, Deaglio, Silvia, Patrono, Damiano, Romagnoli, Renato
Format: Article
Language:English
Subjects:
Ascites
B cells
Biomarkers
Cancer therapies
Cell growth
Extracellular vesicles
Health aspects
Hepatitis
hepatocellular carcinoma
Hypertension
liquid biopsy
Liver
Liver cancer
Liver cirrhosis
Liver diseases
liver transplantation
Liver transplants
machine perfusion
Medical prognosis
Medical research
Medicine, Experimental
MicroRNAs
Mortality
Nucleic acids
Physiological aspects
Plasma
Proteins
rejection
Review
Steroids
Transplantation
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Summary:Extracellular vesicles (EVs) are emerging as a promising field of research in liver disease. EVs are small, membrane-bound vesicles that contain various bioactive molecules, such as proteins, lipids, and nucleic acids and are involved in intercellular communication. They have been implicated in numerous physiological and pathological processes, including immune modulation and tissue repair, which make their use appealing in liver transplantation (LT). This review summarizes the current state of knowledge regarding the role of EVs in LT, including their potential use as biomarkers and therapeutic agents and their role in graft rejection. By providing a comprehensive insight into this emerging topic, this research lays the groundwork for the potential application of EVs in LT.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241713547