Marine Invertebrate Antimicrobial Peptides and Their Potential as Novel Peptide Antibiotics

Marine invertebrates constantly interact with a wide range of microorganisms in their aquatic environment and possess an effective defense system that has enabled their existence for millions of years. Their lack of acquired immunity sets marine invertebrates apart from other marine animals. Inverte...

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Bibliographic Details
Published in:Marine drugs 2023-09, Vol.21 (10), p.503
Main Authors: Guryanova, Svetlana V, Balandin, Sergey V, Belogurova-Ovchinnikova, Oksana Yu, Ovchinnikova, Tatiana V
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Antibiotic resistance
Antibiotics
Antimicrobial agents
Antimicrobial peptides
Aquatic environment
Aquatic microorganisms
Bacteria
Bioactive compounds
Biological activity
Biosynthesis
Chemical bonds
Cytotoxicity
Defense mechanisms
Dosage and administration
Drug development
Drug resistance
Drug resistance in microorganisms
Drugs
Fungi
Gene expression
Genetic aspects
Gram-negative bacteria
Gram-positive bacteria
Health aspects
host defense peptides
Identification and classification
Immune system
Immunity
Immunosuppressive agents
Innate immunity
Invertebrates
Marine animals
Marine biology
Marine invertebrates
Marine organisms
Microbiological strains
Microorganisms
Mollusks
Pathogens
Peptide antibiotics
Peptides
Prevention
Protozoa
Review
Survival
Taxonomy
Viruses
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Summary:Marine invertebrates constantly interact with a wide range of microorganisms in their aquatic environment and possess an effective defense system that has enabled their existence for millions of years. Their lack of acquired immunity sets marine invertebrates apart from other marine animals. Invertebrates could rely on their innate immunity, providing the first line of defense, survival, and thriving. The innate immune system of marine invertebrates includes various biologically active compounds, and specifically, antimicrobial peptides. Nowadays, there is a revive of interest in these peptides due to the urgent need to discover novel drugs against antibiotic-resistant bacterial strains, a pressing global concern in modern healthcare. Modern technologies offer extensive possibilities for the development of innovative drugs based on these compounds, which can act against bacteria, fungi, protozoa, and viruses. This review focuses on structural peculiarities, biological functions, gene expression, biosynthesis, mechanisms of antimicrobial action, regulatory activities, and prospects for the therapeutic use of antimicrobial peptides derived from marine invertebrates.
ISSN:1660-3397
1660-3397
DOI:10.3390/md21100503