CEUS LI-RADS for diagnosis of hepatocellular carcinoma in individuals without LI-RADS-defined hepatocellular carcinoma risk factors

This study evaluated the performance of the contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) in patients without LI-RADS-defined hepatocellular carcinoma (HCC) risk factors (RF-). Patients with LI-RADS-defined HCC risk factors (RF+) and RF- were enrolled in a ret...

Full description

Saved in:
Bibliographic Details
Published in:Cancer imaging 2023-03, Vol.23 (1), p.24-24, Article 24
Main Authors: Huang, Zhe, Zhou, Ping Ping, Li, Shan Shan, Li, Kaiyan
Format: Article
Language:English
Subjects:
Agreements
Algorithms
Cancer therapies
Carcinoma, Hepatocellular - diagnostic imaging
Contrast-Enhanced Ultrasound
Criteria
Data systems
Diagnosis
Hepatitis B
Hepatocellular carcinoma
Hepatoma
Histopathology
Humans
Infections
Liver
Liver cancer
Liver cirrhosis
Liver Neoplasms - diagnostic imaging
Patients
Performance evaluation
Prospective Studies
Retrospective Studies
Risk Factors
Ultrasonic imaging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study evaluated the performance of the contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) in patients without LI-RADS-defined hepatocellular carcinoma (HCC) risk factors (RF-). Patients with LI-RADS-defined HCC risk factors (RF+) and RF- were enrolled in a retrospective study. Additionally, a prospective evaluation in the same centre was performed as a validation set. The diagnostic performances of the CEUS LI-RADS criteria in RF+ and RF- patients were compared. Overall, we included 873 patients in the analyses. In the retrospective study, the LI-RADS category (LR)-5 specificities for diagnosing HCC did not differ between the RF+ and RF- groups (77.5% [158/204] vs 91.6% [196/214], P = 0.369, respectively). However, the positive predictive value (PPV) of CEUS LR-5 was 95.9% (162/169) and 89.8% (158/176) in the RF+ and RF- groups, respectively (P = 0.029). In the prospective study, the PPV of LR-5 for HCC lesions was significantly higher in the RF+ group than in the RF- group (P = 0.030). The sensitivity and specificity did not differ between the RF+ and RF- groups (P = 0.845 and P = 0.577, respectively). The CEUS LR-5 criteria shows clinical value for diagnosis of HCC in patients with and without risks.
ISSN:1470-7330
1740-5025
1470-7330
DOI:10.1186/s40644-023-00541-2