Current development of biodegradable polymeric materials for biomedical applications

In the last half-century, the development of biodegradable polymeric materials for biomedical applications has advanced significantly. Biodegradable polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engi...

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Bibliographic Details
Published in:Drug design, development and therapy development and therapy, 2018-01, Vol.12, p.3117-3145
Main Authors: Song, Richard, Murphy, Maxwell, Li, Chenshuang, Ting, Kang, Soo, Chia, Zheng, Zhong
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - metabolism
Biocompatible Materials - pharmacology
Biodegradability
biodegradable
Biodegradation
Biological products
Biological properties
biomaterials
Biomedical engineering
Biomedical materials
Biomedical Research
Degradation
Drug delivery
Drug Delivery Systems
Enzymes
Health aspects
Humans
Ions
Pharmacology
polymeric materials
Polymers
Polymers - chemistry
Polymers - metabolism
Polymers - pharmacology
Prostheses and Implants
Review
Surgical implants
Technology application
Tissue Engineering
Wound care
Wound healing
Wound Healing - drug effects
Wounds
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Summary:In the last half-century, the development of biodegradable polymeric materials for biomedical applications has advanced significantly. Biodegradable polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering. Further advancements have occurred in the utilization of biodegradable polymeric materials for pharmacological applications such as delivery vehicles for controlled/sustained drug release. These applications require particular physicochemical, biological, and degradation properties of the materials to deliver effective therapy. As a result, a wide range of natural or synthetic polymers able to undergo hydrolytic or enzymatic degradation is being studied for biomedical applications. This review outlines the current development of biodegradable natural and synthetic polymeric materials for various biomedical applications, including tissue engineering, temporary implants, wound healing, and drug delivery.
ISSN:1177-8881
1177-8881
DOI:10.2147/DDDT.S165440