Sodium Tungstate (NaW) Decreases Reactive Oxygen Species (ROS) Production in Cells: New Cellular Antioxidant

Diabetic nephropathy (DN) is the leading cause of end-stage renal failure worldwide. Hyperglycemia generates reactive oxygen species (ROS), contributing to diabetic complications, especially in DN. Sodium Tungstate (NaW) is an effective antidiabetic agent for short and long-term treatments of both t...

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Published in:Biomedicines 2023-01, Vol.11 (2), p.417
Main Authors: Yañez, Alejandro J, Jaramillo, Karen, Blaña, Camila, Burgos, Rafael A, Isla, Adolfo, Silva, Pamela, Aguilar, Marcelo
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antioxidants
Brief Report
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes mellitus (non-insulin dependent)
diabetic nephropathy
End-stage renal disease
Flow cytometry
Glucose
Hydrogen peroxide
Hyperglycemia
Kidney diseases
Leukocytes (neutrophilic)
Nephropathy
Neutrophils
Nitric oxide
Nitric-oxide synthase
Oxidative stress
Platelet-activating factor
Reactive oxygen species
Renal failure
ROS
Sodium
Sodium tungstate
Statistical analysis
Streptozocin
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Summary:Diabetic nephropathy (DN) is the leading cause of end-stage renal failure worldwide. Hyperglycemia generates reactive oxygen species (ROS), contributing to diabetic complications, especially in DN. Sodium Tungstate (NaW) is an effective antidiabetic agent for short and long-term treatments of both type 1 and type 2 diabetes models. In this study, we evaluated the effect of NaW on ROS production in bovine neutrophils incubated with platelet-activating factor (PAF) and in HK-2 cells induced by high glucose or H O . In addition, we evaluated the effect on iNOS expression in the type 1 diabetic rat model induced with streptozotocin (STZ). NaW inhibited ROS production in PAF-induced bovine neutrophils, and human tubular cells (HK-2) were incubated in high glucose or H O . In addition, NaW inhibited iNOS expression in glomeruli and tubular cells in the type 1 diabetic rat. This study demonstrates a new role for NaW as an active antioxidant and its potential use in treating DN.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11020417