Elevated plasma interleukin 21 is associated with higher probability and severity of idiopathic membranous nephropathy

Interleukin 21 (IL-21) is a receptor participating in innate immunity and correlates with the activation of innate immune cells. We sought to investigate the role of plasma IL-21 in patients with idiopathic membranous nephropathy (IMN).This was a cross-sectional and case-control study. We analyzed p...

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Bibliographic Details
Published in:Journal of laboratory medicine 2023-06, Vol.47 (3), p.121-127
Main Authors: Liu, Miao, Huang, Di, Liang, Enyu, Deng, Bishun, Huang, Huijie, Zhao, Zilin, Deng, Li, Wang, Xiaowan, Lin, Haibiao, Bao, Kun, Xu, Peng, He, Min
Format: Article
Language:English
Subjects:
24 h urine protein
anti-phospholipase A2 receptor antibody
Antibodies
Biomarkers
Cell activation
Correlation
Cytokines
idiopathic membranous nephropathy
Immune system
Innate immunity
Interleukin 21
Interleukins
Kidney diseases
Membranous nephropathy
Nephropathy
Phospholipase A2
Plasma
Proteins
Receptors
Sensitivity
Serum albumin
Statistical analysis
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Summary:Interleukin 21 (IL-21) is a receptor participating in innate immunity and correlates with the activation of innate immune cells. We sought to investigate the role of plasma IL-21 in patients with idiopathic membranous nephropathy (IMN).This was a cross-sectional and case-control study. We analyzed plasma IL-21 in patients with IMN, with other kidney diseases as the diseased controls (DCs), and the healthy controls (HCs), regarding their associations with the risk of having IMN and IMN severity.We enrolled 132, 22, and 38 patients with IMN, DC, and HC, respectively. Plasma IL-21 was significantly higher in those with IMN [9.42 (6.93, 12.60)] and DC [7.84 (2.90, 7.95)] compared with HC [5.60 (2.90, 7.10)] (p
ISSN:2567-9430
0342-3026
2567-9449
1439-0477
DOI:10.1515/labmed-2022-0149