The impact of statins on psychological wellbeing: a systematic review and meta-analysis

• Published in: BMC medicine 2012-12, Vol.10 (1), p.154-154, Article 154
• Main Authors: O'Neil, Adrienne, Sanna, Livia, Redlich, Cassie, Sanderson, Kristy, Jacka, Felice, Williams, Lana J, Pasco, Julie A, Berk, Michael
• Format: Article
• Language: English
• Subjects: Affect - drug effects; anti-inflammatory; Cholesterol; cytokines; depression; Depression - drug therapy; Depression, Mental; Dosage and administration; Drug therapy; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi; Health Sciences; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Hypercholesterolemia; Hälsovetenskap; Medical and Health Sciences; Medical research; Medicin och hälsovetenskap; Mental depression; Mental Health; mood; oxidative; Pharmaceutical industry; Psychological aspects; Public Health, Global Health, Social Medicine and Epidemiology; Risk factors; Statins; Studies
• ISSN: 1741-7015; 1741-7015
• DOI: 10.1186/1741-7015-10-154

Cholesterol-lowering medications such as statins have anti-inflammatory and antioxidant properties, which may be beneficial for treating depression and improving mood. However, evidence regarding their effects remains inconsistent, with some studies reporting links to mood disturbances. We aimed to conduct a meta-analysis to determine the impact of statins on psychological wellbeing of individuals with or without hypercholesterolemia. Articles were identified using medical, health, psychiatric and social science databases, evaluated for quality, and data were synthesized and analyzed in RevMan-5 software using a random effects model. The 7 randomized controlled trials included in the analysis represented 2,105 participants. A test for overall effect demonstrated no statistically significant differences in psychological wellbeing between participants receiving statins or a placebo (standardized mean difference (SMD) = -0.08, 95% CI -0.29 to 0.12; P = 0.42). Sensitivity analyses were conducted to separately analyze depression (n = 5) and mood (n = 2) outcomes; statins were associated with statistically significant improvements in mood scores (SMD = -0.43, 95% CI -0.61 to -0.24). Our findings refute evidence of negative effects of statins on psychological outcomes, providing some support for mood-related benefits. Future studies could examine the effects of statins in depressed populations.