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The impact of statins on psychological wellbeing: a systematic review and meta-analysis
Cholesterol-lowering medications such as statins have anti-inflammatory and antioxidant properties, which may be beneficial for treating depression and improving mood. However, evidence regarding their effects remains inconsistent, with some studies reporting links to mood disturbances. We aimed to...
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| Published in: | BMC medicine 2012-12, Vol.10 (1), p.154-154, Article 154 |
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| creator | O'Neil, Adrienne Sanna, Livia Redlich, Cassie Sanderson, Kristy Jacka, Felice Williams, Lana J Pasco, Julie A Berk, Michael |
| description | Cholesterol-lowering medications such as statins have anti-inflammatory and antioxidant properties, which may be beneficial for treating depression and improving mood. However, evidence regarding their effects remains inconsistent, with some studies reporting links to mood disturbances. We aimed to conduct a meta-analysis to determine the impact of statins on psychological wellbeing of individuals with or without hypercholesterolemia.
Articles were identified using medical, health, psychiatric and social science databases, evaluated for quality, and data were synthesized and analyzed in RevMan-5 software using a random effects model.
The 7 randomized controlled trials included in the analysis represented 2,105 participants. A test for overall effect demonstrated no statistically significant differences in psychological wellbeing between participants receiving statins or a placebo (standardized mean difference (SMD) = -0.08, 95% CI -0.29 to 0.12; P = 0.42). Sensitivity analyses were conducted to separately analyze depression (n = 5) and mood (n = 2) outcomes; statins were associated with statistically significant improvements in mood scores (SMD = -0.43, 95% CI -0.61 to -0.24).
Our findings refute evidence of negative effects of statins on psychological outcomes, providing some support for mood-related benefits. Future studies could examine the effects of statins in depressed populations. |
| doi_str_mv | 10.1186/1741-7015-10-154 |
| format | article |
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Articles were identified using medical, health, psychiatric and social science databases, evaluated for quality, and data were synthesized and analyzed in RevMan-5 software using a random effects model.
The 7 randomized controlled trials included in the analysis represented 2,105 participants. A test for overall effect demonstrated no statistically significant differences in psychological wellbeing between participants receiving statins or a placebo (standardized mean difference (SMD) = -0.08, 95% CI -0.29 to 0.12; P = 0.42). Sensitivity analyses were conducted to separately analyze depression (n = 5) and mood (n = 2) outcomes; statins were associated with statistically significant improvements in mood scores (SMD = -0.43, 95% CI -0.61 to -0.24).
Our findings refute evidence of negative effects of statins on psychological outcomes, providing some support for mood-related benefits. Future studies could examine the effects of statins in depressed populations.</description><identifier>ISSN: 1741-7015</identifier><identifier>EISSN: 1741-7015</identifier><identifier>DOI: 10.1186/1741-7015-10-154</identifier><identifier>PMID: 23206308</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Affect - drug effects ; anti-inflammatory ; Cholesterol ; cytokines ; depression ; Depression - drug therapy ; Depression, Mental ; Dosage and administration ; Drug therapy ; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ; Health Sciences ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Hypercholesterolemia ; Hälsovetenskap ; Medical and Health Sciences ; Medical research ; Medicin och hälsovetenskap ; Mental depression ; Mental Health ; mood ; oxidative ; Pharmaceutical industry ; Psychological aspects ; Public Health, Global Health, Social Medicine and Epidemiology ; Risk factors ; Statins ; Studies</subject><ispartof>BMC medicine, 2012-12, Vol.10 (1), p.154-154, Article 154</ispartof><rights>COPYRIGHT 2012 BioMed Central Ltd.</rights><rights>2012 O'Neil et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright ©2012 O'Neil et al; licensee BioMed Central Ltd. 2012 O'Neil et al; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-eeac6baec2fd7aa14319b0fce3a8d866eae51597ba3f445488b66273e2080ee3</citedby><cites>FETCH-LOGICAL-c587t-eeac6baec2fd7aa14319b0fce3a8d866eae51597ba3f445488b66273e2080ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568015/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1285172658?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,25740,27911,27912,36999,37000,44577,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23206308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/3674821$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Neil, Adrienne</creatorcontrib><creatorcontrib>Sanna, Livia</creatorcontrib><creatorcontrib>Redlich, Cassie</creatorcontrib><creatorcontrib>Sanderson, Kristy</creatorcontrib><creatorcontrib>Jacka, Felice</creatorcontrib><creatorcontrib>Williams, Lana J</creatorcontrib><creatorcontrib>Pasco, Julie A</creatorcontrib><creatorcontrib>Berk, Michael</creatorcontrib><title>The impact of statins on psychological wellbeing: a systematic review and meta-analysis</title><title>BMC medicine</title><addtitle>BMC Med</addtitle><description>Cholesterol-lowering medications such as statins have anti-inflammatory and antioxidant properties, which may be beneficial for treating depression and improving mood. However, evidence regarding their effects remains inconsistent, with some studies reporting links to mood disturbances. We aimed to conduct a meta-analysis to determine the impact of statins on psychological wellbeing of individuals with or without hypercholesterolemia.
Articles were identified using medical, health, psychiatric and social science databases, evaluated for quality, and data were synthesized and analyzed in RevMan-5 software using a random effects model.
The 7 randomized controlled trials included in the analysis represented 2,105 participants. A test for overall effect demonstrated no statistically significant differences in psychological wellbeing between participants receiving statins or a placebo (standardized mean difference (SMD) = -0.08, 95% CI -0.29 to 0.12; P = 0.42). Sensitivity analyses were conducted to separately analyze depression (n = 5) and mood (n = 2) outcomes; statins were associated with statistically significant improvements in mood scores (SMD = -0.43, 95% CI -0.61 to -0.24).
Our findings refute evidence of negative effects of statins on psychological outcomes, providing some support for mood-related benefits. Future studies could examine the effects of statins in depressed populations.</description><subject>Affect - drug effects</subject><subject>anti-inflammatory</subject><subject>Cholesterol</subject><subject>cytokines</subject><subject>depression</subject><subject>Depression - drug therapy</subject><subject>Depression, Mental</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi</subject><subject>Health Sciences</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</subject><subject>Hypercholesterolemia</subject><subject>Hälsovetenskap</subject><subject>Medical and Health Sciences</subject><subject>Medical research</subject><subject>Medicin och hälsovetenskap</subject><subject>Mental depression</subject><subject>Mental Health</subject><subject>mood</subject><subject>oxidative</subject><subject>Pharmaceutical industry</subject><subject>Psychological aspects</subject><subject>Public Health, Global Health, Social Medicine and Epidemiology</subject><subject>Risk factors</subject><subject>Statins</subject><subject>Studies</subject><issn>1741-7015</issn><issn>1741-7015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptks2LEzEUwAdR3HX17kkGBPEyaz4nGQ_CsvixUPBS8BheMi9tysykTqZb-t-btmtpRUJIePm9X8LLK4q3lNxSqutPVAlaKUJlRUlFpXhWXJ9Cz8_2V8WrlFaEMKmUeFlcMc5IzYm-Ln7Nl1iGfg1uKqMv0wRTGFIZh3Kddm4Zu7gIDrpyi11nMQyLzyWUaZcm7DPpyhEfA25LGNqyxwkqGKDbpZBeFy88dAnfPK03xfzb1_n9j2r28_vD_d2sclKrqUIEV1tAx3yrAKjgtLHEO-SgW13XCCipbJQF7oWQQmtb10xxZEQTRH5TPBy1bYSVWY-hh3FnIgRzCMRxYWDM7-zQeM2VRSs9a5hAxgFEo1vkGhvqCSfZNTu60hbXG3th6zbrPG2eJqGhmlBoVGuUotwIZsFY3xKDwjLe-IY04LLuy1GXXT22DodphO7CenkyhKVZxEfDZZ39Mgs-PgnG-HuDaTJ9SC7_AwwYN8lQputGiEbojL7_B13FzZi_4kBJqlgtz6gF5HqEwcd8r9tLzZ3kgtZK8T11-x8qjxb74OKAPuT4RcKHs4QlQjctU-w2U4hDugTJEXRjTGlEfyoGJWbfz2bfsGbfsIeIFDnl3XkRTwl_G5j_ATff7pA</recordid><startdate>20121203</startdate><enddate>20121203</enddate><creator>O'Neil, Adrienne</creator><creator>Sanna, Livia</creator><creator>Redlich, Cassie</creator><creator>Sanderson, Kristy</creator><creator>Jacka, Felice</creator><creator>Williams, Lana J</creator><creator>Pasco, Julie A</creator><creator>Berk, Michael</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AGCHP</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D95</scope><scope>ZZAVC</scope><scope>DOA</scope></search><sort><creationdate>20121203</creationdate><title>The impact of statins on psychological wellbeing: a systematic review and meta-analysis</title><author>O'Neil, Adrienne ; Sanna, Livia ; Redlich, Cassie ; Sanderson, Kristy ; Jacka, Felice ; Williams, Lana J ; Pasco, Julie A ; Berk, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-eeac6baec2fd7aa14319b0fce3a8d866eae51597ba3f445488b66273e2080ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Affect - drug effects</topic><topic>anti-inflammatory</topic><topic>Cholesterol</topic><topic>cytokines</topic><topic>depression</topic><topic>Depression - drug therapy</topic><topic>Depression, Mental</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi</topic><topic>Health Sciences</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</topic><topic>Hypercholesterolemia</topic><topic>Hälsovetenskap</topic><topic>Medical and Health Sciences</topic><topic>Medical research</topic><topic>Medicin och hälsovetenskap</topic><topic>Mental depression</topic><topic>Mental Health</topic><topic>mood</topic><topic>oxidative</topic><topic>Pharmaceutical industry</topic><topic>Psychological aspects</topic><topic>Public Health, Global Health, Social Medicine and Epidemiology</topic><topic>Risk factors</topic><topic>Statins</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Neil, Adrienne</creatorcontrib><creatorcontrib>Sanna, Livia</creatorcontrib><creatorcontrib>Redlich, Cassie</creatorcontrib><creatorcontrib>Sanderson, Kristy</creatorcontrib><creatorcontrib>Jacka, Felice</creatorcontrib><creatorcontrib>Williams, Lana J</creatorcontrib><creatorcontrib>Pasco, Julie A</creatorcontrib><creatorcontrib>Berk, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Lunds universitet</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Neil, Adrienne</au><au>Sanna, Livia</au><au>Redlich, Cassie</au><au>Sanderson, Kristy</au><au>Jacka, Felice</au><au>Williams, Lana J</au><au>Pasco, Julie A</au><au>Berk, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of statins on psychological wellbeing: a systematic review and meta-analysis</atitle><jtitle>BMC medicine</jtitle><addtitle>BMC Med</addtitle><date>2012-12-03</date><risdate>2012</risdate><volume>10</volume><issue>1</issue><spage>154</spage><epage>154</epage><pages>154-154</pages><artnum>154</artnum><issn>1741-7015</issn><eissn>1741-7015</eissn><abstract>Cholesterol-lowering medications such as statins have anti-inflammatory and antioxidant properties, which may be beneficial for treating depression and improving mood. However, evidence regarding their effects remains inconsistent, with some studies reporting links to mood disturbances. We aimed to conduct a meta-analysis to determine the impact of statins on psychological wellbeing of individuals with or without hypercholesterolemia.
Articles were identified using medical, health, psychiatric and social science databases, evaluated for quality, and data were synthesized and analyzed in RevMan-5 software using a random effects model.
The 7 randomized controlled trials included in the analysis represented 2,105 participants. A test for overall effect demonstrated no statistically significant differences in psychological wellbeing between participants receiving statins or a placebo (standardized mean difference (SMD) = -0.08, 95% CI -0.29 to 0.12; P = 0.42). Sensitivity analyses were conducted to separately analyze depression (n = 5) and mood (n = 2) outcomes; statins were associated with statistically significant improvements in mood scores (SMD = -0.43, 95% CI -0.61 to -0.24).
Our findings refute evidence of negative effects of statins on psychological outcomes, providing some support for mood-related benefits. Future studies could examine the effects of statins in depressed populations.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23206308</pmid><doi>10.1186/1741-7015-10-154</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Affect - drug effects anti-inflammatory Cholesterol cytokines depression Depression - drug therapy Depression, Mental Dosage and administration Drug therapy Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Health Sciences Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hypercholesterolemia Hälsovetenskap Medical and Health Sciences Medical research Medicin och hälsovetenskap Mental depression Mental Health mood oxidative Pharmaceutical industry Psychological aspects Public Health, Global Health, Social Medicine and Epidemiology Risk factors Statins Studies |
| title | The impact of statins on psychological wellbeing: a systematic review and meta-analysis |
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