Advancing precision in histocompatibility and immunogenetics: a comprehensive review of the UCLA exchange program

Precise typing of human leukocyte antigens (HLA) is crucial for clinical hematopoietic stem cell and solid organ transplantations, transfusion medicine, HLA-related disease association, and drug hypersensitivity analysis. The UCLA Cell Exchange program has played a vital role in providing educationa...

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Bibliographic Details
Published in:Frontiers in genetics 2024-02, Vol.15, p.1352764-1352764
Main Authors: Zhang, Qiuheng, Locke, Arlene F, Alvarez, Andrea Carolina, Cabarong, Maria L, Liv, Lek Ching, Alfaro, Belen Garcia P, Gjertson, David W, Reed, Elaine F
Format: Article
Language:English
Subjects:
Genetics
HLA
HLA antibody
KIR
MICA
physical crossmatch
virtual crossmatch
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Summary:Precise typing of human leukocyte antigens (HLA) is crucial for clinical hematopoietic stem cell and solid organ transplantations, transfusion medicine, HLA-related disease association, and drug hypersensitivity analysis. The UCLA Cell Exchange program has played a vital role in providing educational and proficiency testing surveys to HLA laboratories worldwide for the past 5 decades. This article highlights the significant contribution of the UCLA Cell and DNA Exchange Programs in advancing HLA antibody testing, genotyping, crossmatches, and, more recently, virtual crossmatches. Additionally, we discuss future directions of the UCLA Cell Exchange program to support histocompatibility testing to adapt to the fast-evolving field of immunotherapy, tolerance and xenotransplantation.
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2024.1352764