Effectiveness of radiotherapy to prevent recurrence of heterotopic ossification in patients with spinal cord injury and traumatic head injury: A retrospective case-controlled study

• Published in: Journal of rehabilitation medicine 2020-05, Vol.52 (5), p.jrm00066-jrm00066
• Main Authors: Honore, Thibaud, Bonan, Isabelle, Salga, Marjorie, Denormandie, Philippe, Labib, Alain, Genet, Guillaume, Grelier, Amandine, Genet, Francois
• Format: Article
• Language: English
• Subjects: excision; heterotopic ossification; Life Sciences; radiotherapy; recurrence; spinal cord injury; traumatic brain injury
• ISSN: 1650-1977; 1651-2081
• DOI: 10.2340/16501977-2692

To evaluate recurrence and early postoperative complications (sepsis) following surgical excision combined with radiotherapy for troublesome hip heterotopic ossification in patients with spinal cord injury and traumatic brain injury. Retrospective case-control study. Data relating to patients with spinal cord injury or traumatic brain injury who underwent surgical excision of hip heterotopic ossification were retrieved from the BANKHO database. Case patients underwent excision + radiotherapy and controls underwent excision only. Control patients were matched to case patients according to sex and age (± 4 years). Data from 19 case patients and 76 controls were analysed. Not applicable. The primary end-point was recurrence of heterotopic ossification. Secondary end-points were postoperative complications and, more specifically, sepsis that required surgical revision. There was no difference between the odds ratios (OR) for recurrence for each group (OR case group = 0.63, OR spinal cord injury subgroup = 0.45 and OR head injury subgroup = 1.04). The rate of sepsis requiring surgical revision was significantly higher in the case group (p