Acute Efavirenz Intoxication in a 16-year-old HIV Negative Girl: A Case Report and Literature Review

Background: There are only rare case reports that revealed the efavirenz (EFV) toxicity. Case Report: This study presents an acute intoxication with 12 g of efavirenz in a 16-year-old healthy girl whose main problem was dose-dependent neurotoxicity. No other serious EFV-related side effects were see...

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Bibliographic Details
Published in:Pharmaceutical and biomedical research 2024-12, Vol.10 (1), p.73-78
Main Authors: Moghimi, Minoo, Nekoukar, Zahra, Khosravi, Navid
Format: Article
Language:English
Subjects:
efavirenz
human immunodeficiency virus
intoxication
neurotoxicity
toxicology
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Summary:Background: There are only rare case reports that revealed the efavirenz (EFV) toxicity. Case Report: This study presents an acute intoxication with 12 g of efavirenz in a 16-year-old healthy girl whose main problem was dose-dependent neurotoxicity. No other serious EFV-related side effects were seen. Previous serious side effects of EFV were observed in HIV-infected patients who underwent long-term combination drug therapy.  Conclusion: Accordingly, in terms of the key clinical messages, serious adverse effects of efavirenz are expected to be observed in long-term use in combination with other antiretroviral drugs.
ISSN:2423-4486
2423-4494
DOI:10.32598/PBR.10.1.931.1