Outcomes and complications of percutaneous device closure in adults with secundum atrial septal defect

To assess immediate outcome and complications of Amplatzer septal occluder percutaneous device for closure of secundum atrial septal defect in adults, and to determine regression in right ventricular size, reduced pulmonary arterial systolic pressure and incidence of device embolization at follow-up...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2022-02, Vol.72 (2), p.385-389
Main Authors: Bashir, Faiza, Hameed, Maryam, Hanif, Bashir, Aijaz, Saba
Format: Article
Language:English
Subjects:
Adult
Atrial septal defects
Cardiovascular equipment
Care and treatment
Chest
Embolization, Therapeutic - adverse effects
Female
Heart Septal Defects, Atrial - diagnostic imaging
Heart Septal Defects, Atrial - surgery
Humans
Incidence
Middle Aged
Patient outcomes
Septal Occluder Device - adverse effects
Surgery
Treatment Outcome
Young Adult
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 389
container_issue 2
container_start_page 385
container_title Journal of the Pakistan Medical Association
container_volume 72
creator Bashir, Faiza
Hameed, Maryam
Hanif, Bashir
Aijaz, Saba
description To assess immediate outcome and complications of Amplatzer septal occluder percutaneous device for closure of secundum atrial septal defect in adults, and to determine regression in right ventricular size, reduced pulmonary arterial systolic pressure and incidence of device embolization at follow-up. The single-cohort, ambi-directional, observational study was conducted at the Tabba Heart Institute, Karachi, from January 2013 to July 2018, and comprised patients admitted consecutively for percutaneous atrial septal defect closure. Pre-closure trans-oesophageal echocardiogram was performed in all cases to ensure adequacy of defect margins necessary for device stability. Immediate procedure success and complications were determined by trans-oesophageal echocardiogram, while transthoracic echo was done on follow-up. Data was analysed using SPSS 21. Of the 64 patients, 41(71.9%) were females. The overall mean age was 36.6±14 years. Median size of atrial septal defect was 21mm (interquartile range: 17-26mm). Immediate success was observed in 59(92.2%) patients, and there were 5(8%) acute device embolization events. Small residual atrial septal defect was found in 4(6.3%) cases. On 20-month follow-up, 54(84.4%) patients showed improved symptoms. Repeat transthoracic echo was performed in 39(60.1%) cases, and there were no late embolic events or residual atrial septal defect. Right ventricular size normalized in 34(89.5%) cases, mean pulmonary arterial systolic pressure reduced significantly compared to pre-closure measurement (p
doi_str_mv 10.47391/JPMA.106
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_f85b38d1ff8b499fbf52a5fecb6f73ed</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A697122503</galeid><doaj_id>oai_doaj_org_article_f85b38d1ff8b499fbf52a5fecb6f73ed</doaj_id><sourcerecordid>A697122503</sourcerecordid><originalsourceid>FETCH-LOGICAL-c374t-4bb674ec0374e6da9276d7fcd1f19416fe737a55a2ddf0f8bf28a0bf322fd0153</originalsourceid><addsrcrecordid>eNptkl1rFTEQhhdRbK1e-AckIIhenGM-dpPdy0OpWqnUC70O2WTSk5LdrPlQ_PdNz9bSguRi5h2eeckk0zSvCd62gg3k49fv33ZbgvmT5hhjhjfD0NOnD_Kj5kVK1xhT3mH8vDliHaOY4va4sZcl6zBBQmo2qGaLd1plF-aEgkULRF2ymiGUhAz8dhqQ9iGVCMjNSJnic0J_XN6jBLrMpkxI5eiUr3rJNRiwoPPL5plVPsGru3jS_Px09uP0y-bi8vP56e5io5lo86YdRy5a0Lgq4EYNVHAjrDbEkqEl3IJgQnWdosZYbPvR0l7h0TJKrcGkYyfN-eprgrqWS3STin9lUE4eCiFeSRWz0x6k7buR9dW52rTDYEfbUdXVy47cCgamer1fvZYYfhVIWU4uafB-fQ5JeUv7gQguKvp2Ra9UdXazDTkqfYvLHR8EobTDrFLb_1D1GJicDjNYV-uPGt49aNiD8nmfgi-H73kMflhBHUNKEez96ATLw4rI2xWpilf2zd1YZZzA3JP_doLdADe3ti4</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2642891767</pqid></control><display><type>article</type><title>Outcomes and complications of percutaneous device closure in adults with secundum atrial septal defect</title><source>DOAJ Directory of Open Access Journals</source><creator>Bashir, Faiza ; Hameed, Maryam ; Hanif, Bashir ; Aijaz, Saba</creator><creatorcontrib>Bashir, Faiza ; Hameed, Maryam ; Hanif, Bashir ; Aijaz, Saba</creatorcontrib><description>To assess immediate outcome and complications of Amplatzer septal occluder percutaneous device for closure of secundum atrial septal defect in adults, and to determine regression in right ventricular size, reduced pulmonary arterial systolic pressure and incidence of device embolization at follow-up. The single-cohort, ambi-directional, observational study was conducted at the Tabba Heart Institute, Karachi, from January 2013 to July 2018, and comprised patients admitted consecutively for percutaneous atrial septal defect closure. Pre-closure trans-oesophageal echocardiogram was performed in all cases to ensure adequacy of defect margins necessary for device stability. Immediate procedure success and complications were determined by trans-oesophageal echocardiogram, while transthoracic echo was done on follow-up. Data was analysed using SPSS 21. Of the 64 patients, 41(71.9%) were females. The overall mean age was 36.6±14 years. Median size of atrial septal defect was 21mm (interquartile range: 17-26mm). Immediate success was observed in 59(92.2%) patients, and there were 5(8%) acute device embolization events. Small residual atrial septal defect was found in 4(6.3%) cases. On 20-month follow-up, 54(84.4%) patients showed improved symptoms. Repeat transthoracic echo was performed in 39(60.1%) cases, and there were no late embolic events or residual atrial septal defect. Right ventricular size normalized in 34(89.5%) cases, mean pulmonary arterial systolic pressure reduced significantly compared to pre-closure measurement (p&lt;0.001). Percutaneous atrial septal defect closure was found to be safe and effective in adults with secundum atrial septal defect. Timely closure resulted in improved symptoms, right ventricular remodelling and reduced pulmonary arterial systolic pressure at intermediate-term follow-up.</description><identifier>ISSN: 0030-9982</identifier><identifier>EISSN: 0030-9982</identifier><identifier>DOI: 10.47391/JPMA.106</identifier><identifier>PMID: 35320204</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>Adult ; Atrial septal defects ; Cardiovascular equipment ; Care and treatment ; Chest ; Embolization, Therapeutic - adverse effects ; Female ; Heart Septal Defects, Atrial - diagnostic imaging ; Heart Septal Defects, Atrial - surgery ; Humans ; Incidence ; Middle Aged ; Patient outcomes ; Septal Occluder Device - adverse effects ; Surgery ; Treatment Outcome ; Young Adult</subject><ispartof>Journal of the Pakistan Medical Association, 2022-02, Vol.72 (2), p.385-389</ispartof><rights>COPYRIGHT 2022 Knowledge Bylanes</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,2095,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35320204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bashir, Faiza</creatorcontrib><creatorcontrib>Hameed, Maryam</creatorcontrib><creatorcontrib>Hanif, Bashir</creatorcontrib><creatorcontrib>Aijaz, Saba</creatorcontrib><title>Outcomes and complications of percutaneous device closure in adults with secundum atrial septal defect</title><title>Journal of the Pakistan Medical Association</title><addtitle>J Pak Med Assoc</addtitle><description>To assess immediate outcome and complications of Amplatzer septal occluder percutaneous device for closure of secundum atrial septal defect in adults, and to determine regression in right ventricular size, reduced pulmonary arterial systolic pressure and incidence of device embolization at follow-up. The single-cohort, ambi-directional, observational study was conducted at the Tabba Heart Institute, Karachi, from January 2013 to July 2018, and comprised patients admitted consecutively for percutaneous atrial septal defect closure. Pre-closure trans-oesophageal echocardiogram was performed in all cases to ensure adequacy of defect margins necessary for device stability. Immediate procedure success and complications were determined by trans-oesophageal echocardiogram, while transthoracic echo was done on follow-up. Data was analysed using SPSS 21. Of the 64 patients, 41(71.9%) were females. The overall mean age was 36.6±14 years. Median size of atrial septal defect was 21mm (interquartile range: 17-26mm). Immediate success was observed in 59(92.2%) patients, and there were 5(8%) acute device embolization events. Small residual atrial septal defect was found in 4(6.3%) cases. On 20-month follow-up, 54(84.4%) patients showed improved symptoms. Repeat transthoracic echo was performed in 39(60.1%) cases, and there were no late embolic events or residual atrial septal defect. Right ventricular size normalized in 34(89.5%) cases, mean pulmonary arterial systolic pressure reduced significantly compared to pre-closure measurement (p&lt;0.001). Percutaneous atrial septal defect closure was found to be safe and effective in adults with secundum atrial septal defect. Timely closure resulted in improved symptoms, right ventricular remodelling and reduced pulmonary arterial systolic pressure at intermediate-term follow-up.</description><subject>Adult</subject><subject>Atrial septal defects</subject><subject>Cardiovascular equipment</subject><subject>Care and treatment</subject><subject>Chest</subject><subject>Embolization, Therapeutic - adverse effects</subject><subject>Female</subject><subject>Heart Septal Defects, Atrial - diagnostic imaging</subject><subject>Heart Septal Defects, Atrial - surgery</subject><subject>Humans</subject><subject>Incidence</subject><subject>Middle Aged</subject><subject>Patient outcomes</subject><subject>Septal Occluder Device - adverse effects</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0030-9982</issn><issn>0030-9982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptkl1rFTEQhhdRbK1e-AckIIhenGM-dpPdy0OpWqnUC70O2WTSk5LdrPlQ_PdNz9bSguRi5h2eeckk0zSvCd62gg3k49fv33ZbgvmT5hhjhjfD0NOnD_Kj5kVK1xhT3mH8vDliHaOY4va4sZcl6zBBQmo2qGaLd1plF-aEgkULRF2ymiGUhAz8dhqQ9iGVCMjNSJnic0J_XN6jBLrMpkxI5eiUr3rJNRiwoPPL5plVPsGru3jS_Px09uP0y-bi8vP56e5io5lo86YdRy5a0Lgq4EYNVHAjrDbEkqEl3IJgQnWdosZYbPvR0l7h0TJKrcGkYyfN-eprgrqWS3STin9lUE4eCiFeSRWz0x6k7buR9dW52rTDYEfbUdXVy47cCgamer1fvZYYfhVIWU4uafB-fQ5JeUv7gQguKvp2Ra9UdXazDTkqfYvLHR8EobTDrFLb_1D1GJicDjNYV-uPGt49aNiD8nmfgi-H73kMflhBHUNKEez96ATLw4rI2xWpilf2zd1YZZzA3JP_doLdADe3ti4</recordid><startdate>20220228</startdate><enddate>20220228</enddate><creator>Bashir, Faiza</creator><creator>Hameed, Maryam</creator><creator>Hanif, Bashir</creator><creator>Aijaz, Saba</creator><general>Knowledge Bylanes</general><general>Pakistan Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20220228</creationdate><title>Outcomes and complications of percutaneous device closure in adults with secundum atrial septal defect</title><author>Bashir, Faiza ; Hameed, Maryam ; Hanif, Bashir ; Aijaz, Saba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-4bb674ec0374e6da9276d7fcd1f19416fe737a55a2ddf0f8bf28a0bf322fd0153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Atrial septal defects</topic><topic>Cardiovascular equipment</topic><topic>Care and treatment</topic><topic>Chest</topic><topic>Embolization, Therapeutic - adverse effects</topic><topic>Female</topic><topic>Heart Septal Defects, Atrial - diagnostic imaging</topic><topic>Heart Septal Defects, Atrial - surgery</topic><topic>Humans</topic><topic>Incidence</topic><topic>Middle Aged</topic><topic>Patient outcomes</topic><topic>Septal Occluder Device - adverse effects</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Bashir, Faiza</creatorcontrib><creatorcontrib>Hameed, Maryam</creatorcontrib><creatorcontrib>Hanif, Bashir</creatorcontrib><creatorcontrib>Aijaz, Saba</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of the Pakistan Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bashir, Faiza</au><au>Hameed, Maryam</au><au>Hanif, Bashir</au><au>Aijaz, Saba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes and complications of percutaneous device closure in adults with secundum atrial septal defect</atitle><jtitle>Journal of the Pakistan Medical Association</jtitle><addtitle>J Pak Med Assoc</addtitle><date>2022-02-28</date><risdate>2022</risdate><volume>72</volume><issue>2</issue><spage>385</spage><epage>389</epage><pages>385-389</pages><issn>0030-9982</issn><eissn>0030-9982</eissn><abstract>To assess immediate outcome and complications of Amplatzer septal occluder percutaneous device for closure of secundum atrial septal defect in adults, and to determine regression in right ventricular size, reduced pulmonary arterial systolic pressure and incidence of device embolization at follow-up. The single-cohort, ambi-directional, observational study was conducted at the Tabba Heart Institute, Karachi, from January 2013 to July 2018, and comprised patients admitted consecutively for percutaneous atrial septal defect closure. Pre-closure trans-oesophageal echocardiogram was performed in all cases to ensure adequacy of defect margins necessary for device stability. Immediate procedure success and complications were determined by trans-oesophageal echocardiogram, while transthoracic echo was done on follow-up. Data was analysed using SPSS 21. Of the 64 patients, 41(71.9%) were females. The overall mean age was 36.6±14 years. Median size of atrial septal defect was 21mm (interquartile range: 17-26mm). Immediate success was observed in 59(92.2%) patients, and there were 5(8%) acute device embolization events. Small residual atrial septal defect was found in 4(6.3%) cases. On 20-month follow-up, 54(84.4%) patients showed improved symptoms. Repeat transthoracic echo was performed in 39(60.1%) cases, and there were no late embolic events or residual atrial septal defect. Right ventricular size normalized in 34(89.5%) cases, mean pulmonary arterial systolic pressure reduced significantly compared to pre-closure measurement (p&lt;0.001). Percutaneous atrial septal defect closure was found to be safe and effective in adults with secundum atrial septal defect. Timely closure resulted in improved symptoms, right ventricular remodelling and reduced pulmonary arterial systolic pressure at intermediate-term follow-up.</abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>35320204</pmid><doi>10.47391/JPMA.106</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0030-9982
ispartof Journal of the Pakistan Medical Association, 2022-02, Vol.72 (2), p.385-389
issn 0030-9982
0030-9982
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_f85b38d1ff8b499fbf52a5fecb6f73ed
source DOAJ Directory of Open Access Journals
subjects Adult
Atrial septal defects
Cardiovascular equipment
Care and treatment
Chest
Embolization, Therapeutic - adverse effects
Female
Heart Septal Defects, Atrial - diagnostic imaging
Heart Septal Defects, Atrial - surgery
Humans
Incidence
Middle Aged
Patient outcomes
Septal Occluder Device - adverse effects
Surgery
Treatment Outcome
Young Adult
title Outcomes and complications of percutaneous device closure in adults with secundum atrial septal defect
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T01%3A05%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Outcomes%20and%20complications%20of%20percutaneous%20device%20closure%20in%20adults%20with%20secundum%20atrial%20septal%20defect&rft.jtitle=Journal%20of%20the%20Pakistan%20Medical%20Association&rft.au=Bashir,%20Faiza&rft.date=2022-02-28&rft.volume=72&rft.issue=2&rft.spage=385&rft.epage=389&rft.pages=385-389&rft.issn=0030-9982&rft.eissn=0030-9982&rft_id=info:doi/10.47391/JPMA.106&rft_dat=%3Cgale_doaj_%3EA697122503%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c374t-4bb674ec0374e6da9276d7fcd1f19416fe737a55a2ddf0f8bf28a0bf322fd0153%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2642891767&rft_id=info:pmid/35320204&rft_galeid=A697122503&rfr_iscdi=true