Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer

Oxidative stresses (OSs) are considered a pivotal factor in creating various pathophysiological conditions. Cells have been able to move forward by modulating numerous signaling pathways to moderate the defects of these stresses during their evolution. The company of Kelch-like ECH-associated protei...

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Bibliographic Details
Published in:Antioxidants 2023-03, Vol.12 (3), p.735
Main Authors: Ghareghomi, Somayyeh, Moosavi-Movahedi, Faezeh, Saso, Luciano, Habibi-Rezaei, Mehran, Khatibi, Ali, Hong, Jun, Moosavi-Movahedi, Ali A
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
Cell growth
Gene expression
Heme
Heme oxygenase (decyclizing)
Heme oxygenase-1
Keap/Nrf2 pathway
Kinases
Lung cancer
Mitochondrial DNA
Oxidation
Oxidative stress
Oxygenase
Physiological aspects
Review
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Summary:Oxidative stresses (OSs) are considered a pivotal factor in creating various pathophysiological conditions. Cells have been able to move forward by modulating numerous signaling pathways to moderate the defects of these stresses during their evolution. The company of Kelch-like ECH-associated protein 1 (Keap1) as a molecular sensing element of the oxidative and electrophilic stress and nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) as a master transcriptional regulator of the antioxidant response makes a master cytoprotective antioxidant pathway known as the Keap1/Nrf2 pathway. This pathway is considered a dual-edged sword with beneficial features for both normal and cancer cells by regulating the gene expression of the array of endogenous antioxidant enzymes. Heme oxygenase-1 (HO-1), a critical enzyme in toxic heme removal, is one of the clear state indicators for the duality of this pathway. Therefore, Nrf2/HO-1 axis targeting is known as a novel strategy for cancer treatment. In this review, the molecular mechanism of action of natural antioxidants on lung cancer cells has been investigated by relying on the Nrf2/HO-1 axis.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox12030735