Association and mediation analyses among multiple metals exposure, plasma folate, and community-based impaired estimated glomerular filtration rate in central Taiwan

Chronic kidney disease (CKD) is increasing, with heavy metal exposure an important risk factor. Additionally, the antioxidant folic acid has been studied for reducing blood arsenic levels and related tissue damage. Therefore, we explored the association and mediation effects among various heavy meta...

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Published in:Environmental health 2022-04, Vol.21 (1), p.44-44, Article 44
Main Authors: Chung, Mu-Chi, Hsu, Hui-Tsung, Mao, Yan-Chiao, Wu, Chin-Ching, Ho, Chih-Te, Liu, Chiu-Shong, Chung, Chi-Jung
Format: Article
Language:English
Subjects:
Adult
Antioxidants
Arsenic
Biomonitoring
Blood
Blood levels
Cadmium
Cholesterol
Chromium
Chronic kidney disease
Chronic kidney failure
Confidence intervals
Cross-Sectional Studies
Deoxyguanosine
Diabetes
Environmental aspects
Environmental health
Epidemiology
Epidermal growth factor receptors
Exposure
Fasting
Female
Folate
Folic Acid
Glomerular Filtration Rate
Health aspects
Heavy metals
High density lipoprotein
Humans
Hypertension
Insulin resistance
Kidney diseases
Lead
Male
Mass spectrometry
Mediation Analysis
Metal concentrations
Metals
Metals, Heavy
Nickel
Oxidative stress
Physiological aspects
Plasma
Pollutants
Prevention
Prospective Studies
Questionnaires
Regression analysis
Renal Insufficiency, Chronic - chemically induced
Renal Insufficiency, Chronic - epidemiology
Risk analysis
Risk factors
Scientific imaging
Smoking
Statistical analysis
Taiwan - epidemiology
Uric Acid
Vitamin B
Weighted quantile sum regression
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Summary:Chronic kidney disease (CKD) is increasing, with heavy metal exposure an important risk factor. Additionally, the antioxidant folic acid has been studied for reducing blood arsenic levels and related tissue damage. Therefore, we explored the association and mediation effects among various heavy metal levels in blood, plasma folate, other CKD risk factors, and impaired estimated glomerular filtration rate (eGFR). We constructed a community-based cross-sectional study from the Human Biomonitoring and Environmental Health Program in central Taiwan. A total of 1643 participants had lived locally for > 5 years, > 40 years old, and completely received health examinations and biospecimen collections. Impaired eGFR was defined as one single eGFR
ISSN:1476-069X
1476-069X
DOI:10.1186/s12940-022-00855-x