Cardiovascular responses to microinjection of trans-(+/-)-ACPD into the NTS were similar in conscious and chloralose-anesthetized rats

The changes in mean arterial pressure (MAP) and heart rate (HR) in response to the activation of metabotropic receptors in the nucleus tractus solitarii (NTS) with trans-(+/-)-1-amino-1,3-cyclopentanedicarboxylic acid (trans-(+/-)-ACPD) were evaluated in conscious and anesthetized Wistar, male rats...

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Bibliographic Details
Published in:Brazilian journal of medical and biological research 1998-04, Vol.31 (4), p.573-579
Main Authors: Machado, B H, Bonagamba, L G
Format: Article
Language:English
Subjects:
3-cyclopentanedicarboxylic acid
Analysis of Variance
Anesthetics, Intravenous - pharmacology
Animals
baroreflex
BIOLOGY
Blood Pressure - drug effects
Chloralose - pharmacology
chloralose anesthesia, trans-(±)-1-amino-1
Cycloleucine - pharmacology
excitatory amino acid receptors
Glutamic Acid - pharmacology
Heart Rate - drug effects
ionotropic receptors
L-glutamate
Male
MEDICINE, RESEARCH & EXPERIMENTAL
Microinjections
neurotransmission
Rats
Rats, Wistar
Solitary Nucleus - drug effects
trans-(±)-ACPD
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Summary:The changes in mean arterial pressure (MAP) and heart rate (HR) in response to the activation of metabotropic receptors in the nucleus tractus solitarii (NTS) with trans-(+/-)-1-amino-1,3-cyclopentanedicarboxylic acid (trans-(+/-)-ACPD) were evaluated in conscious and anesthetized Wistar, male rats weighing 240-260 g (N = 8). The responses obtained with trans-(+/-)-ACPD were compared with the responses to L-glutamate (1 nmol/100 nl), since in a previous study we showed that anesthesia converted a pressor response to L-glutamate microinjected into the NTS of conscious rats to a depressor response in the same rats under urethane or chloralose anesthesia. Microinjection of 3 doses of trans-(+/-)-ACPD (100, 500 and 1000 pmol/100 nl) produced a dose-dependent fall in MAP (range, -20 to -50 mmHg) and HR (range, -30 to -170 bpm) under both conscious and chloralose anesthesia conditions. These data indicate that the cardiovascular responses to the activation of metabotropic receptors by trans-(+/-)-ACPD are not affected by chloralose anesthesia while the cardiovascular responses to the activation of excitatory amino acid (EAA) receptors by L-glutamate are significantly altered.
ISSN:0100-879X
1414-431X
0100-879X
1414-431X
DOI:10.1590/S0100-879X1998000400016