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Antibiotic chemoprophylaxis for leptospirosis: Previous shortcomings and future needs

Leptospirosis is a neglected tropical disease that remains potentially life threatening and hard to diagnose. Climate change combined with overlapping reservoir and human habitats will likely lead to increasing incidence, outbreaks, and mortality in the future. Preventative vaccines are either of li...

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Published in:	Tropical medicine and infectious disease 2024-07, Vol.9 (7), p.1-9
Main Authors:	Petersen, Kyle, Maranich, Ashley
Format:	Article
Language:	English
Subjects:	antibiotic Antibiotics Asymptomatic Bacterial diseases Chemoprevention chemoprophylaxis Climatic changes Diagnosis Disease prevention Diseases Drug dosages Epidemics Epidemiology Floods Health aspects human Infections Leptospirosis Military exercises Mortality Penicillin Prevention Risk factors Serology Side effects Travel Travelers Tropical diseases Typhus Vaccines
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description	Leptospirosis is a neglected tropical disease that remains potentially life threatening and hard to diagnose. Climate change combined with overlapping reservoir and human habitats will likely lead to increasing incidence, outbreaks, and mortality in the future. Preventative vaccines are either of limited scope and availability, or under development. Antibiotic chemoprophylaxis for prevention has been the subject of numerous clinical trials. However, despite 40 years of effort, clinical trials to better define protective efficacy, dosing, and the preferred medication are of poor quality and offer limited evidence. We reviewed the literature and offer critiques of the existing trials as well as potential areas for future exploration that May better define the epidemiology and yield a better evidence base for both travel medicine and public health efforts.
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subjects	antibiotic Antibiotics Asymptomatic Bacterial diseases Chemoprevention chemoprophylaxis Climatic changes Diagnosis Disease prevention Diseases Drug dosages Epidemics Epidemiology Floods Health aspects human Infections Leptospirosis Military exercises Mortality Penicillin Prevention Risk factors Serology Side effects Travel Travelers Tropical diseases Typhus Vaccines
title	Antibiotic chemoprophylaxis for leptospirosis: Previous shortcomings and future needs
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