Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro

Over the past several decades, the incidence of solid cancers has rapidly increased worldwide. Successful removal of tumor-initiating cells within tumors is essential in the field of cancer therapeutics to improve patient disease-free survival rates. The biocompatible multivarient-sized gold nanopar...

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Bibliographic Details
Published in:International journal of nanomedicine 2019-01, Vol.14, p.1131-1148
Main Authors: Wahab, Rizwan, Kaushik, Neha, Khan, Farheen, Kaushik, Nagendra Kumar, Lee, Su-Jae, Choi, Eun Ha, Al-Khedhairy, Abdulaziz A
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
beta Catenin - metabolism
Brain cancer
Brain research
Cancer stem like cells
Cancer therapies
Carcinogenesis - metabolism
Carcinogenesis - pathology
Cell Line, Tumor
Cell Proliferation
Cell Self Renewal
Cell Survival
Chemotherapy
Deoxyribonucleic acid
DNA
Down-Regulation
Drug dosages
Epithelial mesenchymal transition
Glioma
Glioma - pathology
Gold - chemistry
HEK293 Cells
Humans
LOD
LOQ
Metal Nanoparticles - chemistry
Metal Nanoparticles - ultrastructure
Metastasis
Multivarient gold nanoparticles
Nanoparticles
Nanotechnology
Neoplasm Invasiveness
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Original Research
Particle Size
Phenotype
Plasma
Quantum dots
Quantum Dots - chemistry
Quantum Dots - ultrastructure
Signal Transduction
Spheroids, Cellular - metabolism
Spheroids, Cellular - pathology
Stem cells
Studies
Tumors
X-Ray Diffraction
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Summary:Over the past several decades, the incidence of solid cancers has rapidly increased worldwide. Successful removal of tumor-initiating cells within tumors is essential in the field of cancer therapeutics to improve patient disease-free survival rates. The biocompatible multivarient-sized gold nanoparticles (MVS-GNPs) from quantum dots (QDs,
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S195333