The first observation of osmotically neutral sodium accumulation in the myocardial interstitium

The aim of this study was the detection and quantification of the Na + depositions in the extracellular matrix of myocardial tissue, which are suggested to be bound by negatively charged glycosaminoglycan (GAG) structures. The presented experimental results are based on high resolution X-ray fluores...

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Bibliographic Details
Published in:Scientific reports 2021-11, Vol.11 (1), p.22025-22025, Article 22025
Main Authors: Artyukov, I., Arutyunov, G., Bobrov, M., Bukreeva, I., Cedola, A., Dragunov, D., Feshchenko, R., Fratini, M., Mitrokhin, V., Sokolova, A., Vinogradov, A., Gianoncelli, A.
Format: Article
Language:English
Subjects:
631/1647/245
631/1647/245/2225
639/624/400/1106
639/638/440/527/1819
Animals
Comparative analysis
Extracellular matrix
Extracellular Matrix - metabolism
Glycosaminoglycans
Glycosaminoglycans - metabolism
Humanities and Social Sciences
Male
multidisciplinary
Myocardium - metabolism
Osmosis
Rats
Rats, Wistar
Science
Science (multidisciplinary)
Sodium
Sodium - metabolism
X-ray fluorescence
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Summary:The aim of this study was the detection and quantification of the Na + depositions in the extracellular matrix of myocardial tissue, which are suggested to be bound by negatively charged glycosaminoglycan (GAG) structures. The presented experimental results are based on high resolution X-ray fluorescence (XRF) spectromicroscopy technique used to perform a comparative analysis of sodium containment in intracellular and interstitial spaces of cardiac tissues taken from animals selected by low and high sodium intake rates. The experimental results obtained show that high sodium daily intake can result in a remarkable increase of sodium content in the myocardial interstitium.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-01443-8