Generation of urine-derived iPS cell line via a non-integrative method from a Barth syndrome patient with TAZ gene mutation

Human urine cells from a 6-year-old male X-linked Barth syndrome patient harboring a TAZ frameshift (c.517delG, Xq28) were reprogrammed into the induced pluripotent stem cell (iPSC) line WMUi002-A using non-integration CytoTune®-iPS 2.0 Sendai Virus Reprogramming kit, including four well-known Yaman...

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Bibliographic Details
Published in:Stem cell research 2020-08, Vol.47, p.101886-101886, Article 101886
Main Authors: Guo, Xiaoling, Wang, Long, Chen, Kaixin, Song, Shiyang, Wang, Xingang, Gu, Xiaohong, Niu, Chao, Chu, Maoping
Format: Article
Language:English
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Summary:Human urine cells from a 6-year-old male X-linked Barth syndrome patient harboring a TAZ frameshift (c.517delG, Xq28) were reprogrammed into the induced pluripotent stem cell (iPSC) line WMUi002-A using non-integration CytoTune®-iPS 2.0 Sendai Virus Reprogramming kit, including four well-known Yamanaka factors SOX2, OCT4, KLF4, and c-MYC. The established patient-derived iPSC expressed endogenous pluripotent markers, had the potential to differentiate into all of the three germ layers, and displayed a normal karyotype.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2020.101886