Demographic factors associated with hantavirus infection in bank voles (Clethrionomys glareolus)

The bank vole (Clethrionomys glareolus) is the natural reservoir of Puumala virus (PUUV), a species in the genus Hantavirus. PUUV is the etiologic agent of nephropathia epidemica, a mild form of hemorrhagic fever with renal syndrome. Factors that influence hantavirus transmission within host populat...

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Bibliographic Details
Published in:Emerging infectious diseases 2002-09, Vol.8 (9), p.924-929
Main Authors: Olsson, Gert E, White, Neil, Ahlm, Clas, Elgh, Fredrik, Verlemyr, Ann-Christin, Juto, Per, Palo, R Thomas
Format: Article
Language:English
Subjects:
Aging
Animals
Antibodies, Viral - blood
Arvicolinae - physiology
Arvicolinae - virology
bank vole
Body Mass Index
Clethrionomys glareolus
Disease Reservoirs
Disease Susceptibility
Disease transmission
Female
hantavirus
Hantavirus infections
Hantavirus Infections - epidemiology
Hantavirus Infections - transmission
Hantavirus Infections - virology
hemorrhagic fever with renal syndrome
Logistic Models
logistic regression
Male
nephropathia epidemica
Odds Ratio
Population Density
Puumala virus - isolation & purification
Rodent Diseases - epidemiology
Rodent Diseases - transmission
Rodent Diseases - virology
Seasons
Sex Factors
Sweden - epidemiology
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Summary:The bank vole (Clethrionomys glareolus) is the natural reservoir of Puumala virus (PUUV), a species in the genus Hantavirus. PUUV is the etiologic agent of nephropathia epidemica, a mild form of hemorrhagic fever with renal syndrome. Factors that influence hantavirus transmission within host populations are not well understood. We evaluated a number of factors influencing on the association of increased PUUV infection in bank voles captured in a region in northern Sweden endemic for the virus. Logistic regression showed four factors that together correctly predicted 80% of the model outcome: age, body mass index, population phase during sampling (increase, peak, or decline/low), and gender. This analysis highlights the importance of population demography in the successful circulation of hantavirus. The chance of infection was greatest during the peak of the population cycle, implying that the likelihood of exposure to hantavirus increases with increasing population density.
ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid0809.020037