Direct immunofluorescence and immune function in patients with oral lichen planus

Direct immunofluorescence and immune function and patients with oral lichen planusThe etiology of oral lichen planus (OLP) is unknown, our purpose was to evaluate the diagnostic value of direct immunofluorescence (DIF) and to investigate the immune functions in OLP. We enrolled 65 patients with susp...

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Bibliographic Details
Published in:Journal of dental sciences 2022-04, Vol.17 (2), p.795-801
Main Authors: Mao, Fei, Dong, Yunmei, Wang, Zhen, Cai, Luyao, Pan, Dan, Zhang, Chengli, Li, Taiwen, Zhou, Yu
Format: Article
Language:English
Subjects:
Direct immunofluorescence
Histopathologic
Oral lichen planus
Original
REU score
Serologic testing
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Summary:Direct immunofluorescence and immune function and patients with oral lichen planusThe etiology of oral lichen planus (OLP) is unknown, our purpose was to evaluate the diagnostic value of direct immunofluorescence (DIF) and to investigate the immune functions in OLP. We enrolled 65 patients with suspected lesions of OLP and 47 controls. In all participants, clinical and serologic testing were conducted. The histopathologic and DIF tests were conducted in 65 patients. The severity of OLP was evaluated by reticular/hyperkeratotic, erosive/erythematous, ulcerative (REU) scoring system. By hematoxylin and eosin (H&E) staining and DIF examination, 71.2% (42/59) were diagnosed as OLP, 28.8% (17/59) were diagnosed as non-OLP. DIF demonstrated 64.3% positive reactivity with 2 distinct distribution patterns and 8 staining patterns. Compared to the controls, serum IgA in OLP was higher (P 
ISSN:1991-7902
2213-8862
DOI:10.1016/j.jds.2021.10.002