Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial

Background Peripheral neuropathy is not only the most prevalent consequence of diabetes but also the main reason for foot ulceration, disability, and amputation. Therefore, the current study aims to determine the effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic pat...

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Published in:BMC endocrine disorders 2023-10, Vol.23 (1), p.1-224, Article 224
Main Authors: Hassanzadeh, Sajad, Bagheri, Soraya, Majid Ahmadi, Seyed, Ahmadi, Seyed Ahmadreza, Moradishibany, Isaac, Dolatkhah, Hosein, Reisi, Sajjad
Format: Article
Language:English
Subjects:
Amputation
Blood pressure
Care and treatment
Clinical trials
Clonidine
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetic foot
Diabetic neuropathy
Diabetics
Gabapentin
Medical research
Medicine, Experimental
Nervous system
Neuropathic pain
Pain
Patients
Peripheral neuropathy
Prescription drugs
Severity of neuropathic pain
Standard deviation
Type 2 diabetes
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Summary:Background Peripheral neuropathy is not only the most prevalent consequence of diabetes but also the main reason for foot ulceration, disability, and amputation. Therefore, the current study aims to determine the effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients. Methods This 12-week, randomized, and parallel-group trial was conducted to compare the efficacy of oral clonidine and gabapentin with gabapentin alone in diabetic patients in southwest Iran during the first half of 2021. Thirty patients with type 2 diabetes with peripheral neuropathy as assessed by a visual analog scale (VAS) and divided into two groups of 15 patients, treated for up to three months. The data were analyzed using SPSS-21 software. In order to report the results, descriptive indices, independent t-test, one-way analysis of covariance (ANCOVA) and analysis of variance with repeated measures were used. Results The mean and standard deviation of the age of the participants in the clonidine + gabapentin group was equal to 50.20 [+ or -] 7.44, and in the gabapentin group was equal to 50.47 [+ or -] 7.57 (t = 0.10, P-value = 0.923). This research showed a significant difference between the clonidine + gabapentin group and with gabapentin group in terms of neuropathic pain and the severity of neuropathic pain (P < 0.001). Conclusions According to this research results, clonidine + gabapentin can reduce neuropathic pain and the severity of neuropathic pain in diabetic patients. Therefore, it is recommended that healthcare professionals with diabetes expertise prescribe these medications to reduce neuropathic pain and its severity. Trial registration This study was registered in the Iranian Clinical Trials System with the ID (IRCT20211106052983N1) on 14/01/2022. Keywords: Clonidine, Gabapentin, Peripheral neuropathy, Diabetes, Neuropathic pain, Severity of neuropathic pain
ISSN:1472-6823
1472-6823
DOI:10.1186/s12902-023-01486-0