Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases

The prevalence of patients with hyperuricemia or gout is increasing worldwide. Hyperuricemia and gout are primarily attributed to genetic factors, along with lifestyle factors like consuming a purine-rich diet, alcohol and/or fructose intake, and physical activity. While numerous studies have report...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2023-10, Vol.13 (10), p.1519
Main Authors: Kuwabara, Masanari, Fukuuchi, Tomoko, Aoki, Yuhei, Mizuta, Einosuke, Ouchi, Motoshi, Kurajoh, Masafumi, Maruhashi, Tatsuya, Tanaka, Atsushi, Morikawa, Nagisa, Nishimiya, Kensuke, Akashi, Naoyuki, Tanaka, Yoshihiro, Otani, Naoyuki, Morita, Mihoko, Miyata, Hiroshi, Takada, Tappei, Tsutani, Hiroshi, Ogino, Kazuhide, Ichida, Kimiyoshi, Hisatome, Ichiro, Abe, Kohtaro
Format: Article
Language:English
Subjects:
Arteriosclerosis
Asymptomatic
Blood pressure
cardiometabolic diseases
Cardiovascular diseases
Care and treatment
Comorbidity
Complications and side effects
Diabetes
Diabetes mellitus
Diagnosis
Diet
Dosage and administration
Enzymes
Genes
Genetic aspects
Genetic factors
Glucose
Gout
Health aspects
Health risk assessment
Homeostasis
Hypertension
Hyperuricemia
Kidney diseases
Life style
lifestyle
Lifestyles
Liver
Malignancy
Metabolic syndrome
Mutation
Neurological diseases
Physical activity
Physiology
Plasma
Review
Rheumatism
transporters
Uric acid
Urine
Vitamin C
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Summary:The prevalence of patients with hyperuricemia or gout is increasing worldwide. Hyperuricemia and gout are primarily attributed to genetic factors, along with lifestyle factors like consuming a purine-rich diet, alcohol and/or fructose intake, and physical activity. While numerous studies have reported various comorbidities linked to hyperuricemia or gout, the range of these associations is extensive. This review article focuses on the relationship between uric acid and thirteen specific domains: transporters, genetic factors, diet, lifestyle, gout, diabetes mellitus, metabolic syndrome, atherosclerosis, hypertension, kidney diseases, cardiovascular diseases, neurological diseases, and malignancies. The present article provides a comprehensive review of recent developments in these areas, compiled by experts from the Young Committee of the Japanese Society of Gout and Uric and Nucleic Acids. The consolidated summary serves to enhance the global comprehension of uric acid-related matters.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom13101519