Pro-apoptotic and pro-proliferation functions of the JNK pathway of Drosophila: roles in cell competition, tumorigenesis and regeneration

The Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family. It appears to be conserved in all animal species where it regulates important physiological functions involved in apoptosis, cell migration, cell proliferation and regeneration. In this review, we focus on th...

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Bibliographic Details
Published in:Open biology 2019-03, Vol.9 (3), p.180256-180256
Main Authors: Pinal, Noelia, Calleja, Manuel, Morata, Ginés
Format: Article
Language:English
Subjects:
Animals
apoptosis
Apoptosis - physiology
cell competition
Cell Proliferation - physiology
Cell Transformation, Neoplastic - metabolism
Drosophila melanogaster - cytology
Drosophila melanogaster - enzymology
Drosophila melanogaster - physiology
Drosophila Proteins - metabolism
Imaginal Discs - enzymology
JNK Mitogen-Activated Protein Kinases - metabolism
jun n-terminal kinase
MAP Kinase Signaling System - physiology
regeneration
Regeneration - physiology
Review
tumorigenesis
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Summary:The Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family. It appears to be conserved in all animal species where it regulates important physiological functions involved in apoptosis, cell migration, cell proliferation and regeneration. In this review, we focus on the functions of JNK in Drosophila imaginal discs, where it has been reported that it can induce both cell death and cell proliferation. We discuss this apparent paradox in the light of recent findings and propose that the pro-apoptotic and the pro-proliferative functions are intrinsic properties of JNK activity. Whether one function or another is predominant depends on the cellular context.
ISSN:2046-2441
2046-2441
DOI:10.1098/rsob.180256