Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography

Optical coherence tomography angiography (OCTA) enables three-dimensional, high-resolution, depth-resolved flow to be distinguished from non-vessel tissue signals in the retina. Thus, it enables the quantification of the 3D surface area of the retinal vessel signal. Despite the widespread use of OCT...

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Published in:Scientific reports 2022-03, Vol.12 (1), p.3695-3695, Article 3695
Main Authors: Maloca, Peter M., Feu-Basilio, Silvia, Schottenhamml, Julia, Valmaggia, Philippe, Scholl, Hendrik P. N., Rosinés-Fonoll, Josep, Marin-Martinez, Sara, Inglin, Nadja, Reich, Michael, Lange, Clemens, Egan, Catherine, Zweifel, Sandrine, Tufail, Adnan, Spaide, Richard F., Zarranz-Ventura, Javier
Format: Article
Language:English
Subjects:
692/700
692/700/1421
Fluorescein Angiography - methods
Fundus Oculi
Humanities and Social Sciences
Humans
multidisciplinary
Retina
Retinal Vessels - diagnostic imaging
Science
Science (multidisciplinary)
Tomography, Optical Coherence - methods
Visual Acuity
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Summary:Optical coherence tomography angiography (OCTA) enables three-dimensional, high-resolution, depth-resolved flow to be distinguished from non-vessel tissue signals in the retina. Thus, it enables the quantification of the 3D surface area of the retinal vessel signal. Despite the widespread use of OCTA, no representative spatially rendered reference vessel surface area data are published. In this study, the OCTA vessel surface areas in 203 eyes of 107 healthy participants were measured in the 3D domain. A Generalized Linear Model (GLM) model analysis was performed to investigate the effects of sex, age, spherical equivalent, axial length, and visual acuity on the OCTA vessel surface area. The mean overall vessel surface area was 54.53 mm 2 (range from 27.03 to 88.7 mm 2 ). OCTA vessel surface area was slightly negatively correlated with age. However, the GLM model analysis identified axial length as having the strongest effect on OCTA vessel surface area. No significant correlations were found for sex or between left and right eyes. This is the first study to characterize three-dimensional vascular parameters in a population based on OCTA with respect to the vessel surface area.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-07439-2