Sexual Dimorphism in the Expression of Cardiac and Hippocampal Renin-Angiotensin and Kallikrein-Kinin Systems in Offspring from Mice Exposed to Alcohol during Gestation

Prenatal alcohol exposure (PAE) impairs fetal development. Alcohol consumption was shown to modulate the renin-angiotensin system (RAS). This study aimed to analyze the effects of PAE on the expression of the renin-angiotensin system (RAS) and kallikrein-kinin system (KKS) peptide systems in the hip...

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Published in:Antioxidants 2023-02, Vol.12 (3), p.541
Main Authors: da Silva, Gabriel Almeida, Atum, Allan Luís Barboza, de Matos, Leonardo Paroche, Nasuk, Guilherme Rabelo, de Jesus, Bruna Calixto, Gouveia, Telma Luciana Furtado, Baltatu, Ovidiu Constantin, Zamuner, Stella Regina, Silva Júnior, José Antônio
Format: Article
Language:English
Subjects:
Alcohol use
Angiotensin
Animals
Blood pressure
Enzymes
Females
Fetuses
Gene expression
Health aspects
heart
Hippocampus
Hydrogen peroxide
Inflammation
Kallikrein
Kallikreins
kallikrein–kinin system
Males
Ostomy
oxidative stress
Peptides
prenatal alcohol exposure
Prenatal experience
Renin
renin–angiotensin system
Sexual dimorphism
Weaning
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Summary:Prenatal alcohol exposure (PAE) impairs fetal development. Alcohol consumption was shown to modulate the renin-angiotensin system (RAS). This study aimed to analyze the effects of PAE on the expression of the renin-angiotensin system (RAS) and kallikrein-kinin system (KKS) peptide systems in the hippocampus and heart of mice of both sexes. C57Bl/6 mice were exposed to alcohol during pregnancy at a concentration of 10% ( / ). On postnatal day 45 (PN45), mouse hippocampi and left ventricles (LV) were collected and processed for messenger RNA (mRNA) expression of components of the RAS and KKS. In PAE animals, more pronounced expression of and in males and a restored expression in females were observed in both tissues. In LV, increased , , and expressions were also observed in PAE females. Furthermore, high levels of H O were observed in males from the PAE group in both tissues. Taken together, our results suggest that modulation of the expression of these peptidergic systems in PAE females may make them less susceptible to the effects of alcohol.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox12030541