Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10)

The prognosis of acute myeloid leukemia (AML) patients with der(1;7)(q10;p10) who underwent allogeneic hematopoietic stem cell transplantation (allo‐SCT) is unclear due to its rarity. We retrospectively analyzed 151 AML patients with der(1;7)(q10;p10) and compared the findings with those of 853 AML...

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Bibliographic Details
Published in:EJHaem 2023-02, Vol.4 (1), p.251-257
Main Authors: Mizumaki, Hiroki, Ishiyama, Ken, Aoki, Jun, Mori, Jinichi, Mizuno, Shohei, Doki, Noriko, Fukuda, Takahiro, Uchida, Naoyuki, Onizuka, Masahito, Tanaka, Masatsugu, Katayama, Yuta, Ozawa, Yukiyasu, Ikegame, Kazuhiro, Takada, Satoru, Kawakita, Toshiro, Aotsuka, Nobuyuki, Atsuta, Yoshiko, Yanada, Masamitsu
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
additional chromosomal abnormalities
allogeneic hematopoietic stem cell transplantation
AML
Chromosome 7
Chromosome aberrations
Chromosome deletion
der(1
7)(q10
p10)
Graft versus host disease
Hematopoietic stem cells
Leukemia
Medical prognosis
Monosomy
Mortality
Multivariate analysis
Risk factors
Short Report
Short Reports
Stem cell transplantation
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Summary:The prognosis of acute myeloid leukemia (AML) patients with der(1;7)(q10;p10) who underwent allogeneic hematopoietic stem cell transplantation (allo‐SCT) is unclear due to its rarity. We retrospectively analyzed 151 AML patients with der(1;7)(q10;p10) and compared the findings with those of 853 AML patients with monosomy 7 or chromosome 7q deletion (‐7/del(7q)) using Japanese nationwide registry data. The der(1;7)(q10;p10) group showed significantly better transplant outcomes than the ‐7/del(7q) group. In the multivariate analysis of the der(1;7)(q10;p10) group, additional chromosomal abnormalities and a poor performance status significantly influenced the survival. In conclusion, allo‐SCT is a feasible treatment option for AML patients with der(1;7)(q10;p10).
ISSN:2688-6146
2688-6146
DOI:10.1002/jha2.609