Natural Product-Derived Phytochemicals for Influenza A Virus (H1N1) Prevention and Treatment

• Published in: Molecules (Basel, Switzerland) Switzerland), 2024-05, Vol.29 (10), p.2371
• Main Authors: Li, Ruichen, Han, Qianru, Li, Xiaokun, Liu, Xinguang, Jiao, Weijie
• Format: Article
• Language: English
• Subjects: Amino acids; Animals; antiviral agents; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Antiviral drugs; Biological Products - chemistry; Biological Products - pharmacology; Biological Products - therapeutic use; Drug development; Drug resistance; Epidemics; FDA approval; Flavonoids - chemistry; Flavonoids - pharmacology; Flavonoids - therapeutic use; H1N1; Humans; Infections; Influenza; influenza A; Influenza A Virus, H1N1 Subtype - drug effects; Influenza viruses; Influenza, Human - drug therapy; Influenza, Human - prevention & control; Isoflavones; Li Siguang; Mutation; Natural products; Natural resources; Pandemics; Phytochemicals - chemistry; Phytochemicals - pharmacology; Phytochemicals - therapeutic use; Proteins; RNA polymerase; South China Sea; Viruses
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29102371

Influenza A (H1N1) viruses are prone to antigenic mutations and are more variable than other influenza viruses. Therefore, they have caused continuous harm to human public health since the pandemic in 2009 and in recent times. Influenza A (H1N1) can be prevented and treated in various ways, such as direct inhibition of the virus and regulation of human immunity. Among antiviral drugs, the use of natural products in treating influenza has a long history, and natural medicine has been widely considered the focus of development programs for new, safe anti-influenza drugs. In this paper, we focus on influenza A (H1N1) and summarize the natural product-derived phytochemicals for influenza A virus (H1N1) prevention and treatment, including marine natural products, flavonoids, alkaloids, terpenoids and their derivatives, phenols and their derivatives, polysaccharides, and derivatives of natural products for prevention and treatment of influenza A (H1N1) virus. We further discuss the toxicity and antiviral mechanism against influenza A (H1N1) as well as the druggability of natural products. We hope that this review will facilitate the study of the role of natural products against influenza A (H1N1) activity and provide a promising alternative for further anti-influenza A drug development.