Metabolic Syndrome in Rheumatoid Arthritis

Insulin resistance is an essential feature of the metabolic syndrome that has been linked to rheumatoid arthritis (RA). Understanding how inflammation arising in one tissue affects the physiology and pathology of other organs remains an unanswered question with therapeutic implications for chronic c...

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Bibliographic Details
Published in:Mediators of Inflammation 2013-01, Vol.2013 (2013), p.402-412-245
Main Authors: Iván Ferraz-Amaro, Carlos González-Juanatey, Raquel López-Mejias, Leyre Riancho-Zarrabeitia, Miguel A. González-Gay
Format: Article
Language:English
Subjects:
Animals
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - metabolism
Cardiovascular diseases
Complications and side effects
Humans
Inflammation - metabolism
Insulin resistance
Insulin Resistance - physiology
Metabolic Syndrome - immunology
Metabolic Syndrome - metabolism
Review
Rheumatoid arthritis
Risk factors
Tumor Necrosis Factor-alpha - metabolism
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Summary:Insulin resistance is an essential feature of the metabolic syndrome that has been linked to rheumatoid arthritis (RA). Understanding how inflammation arising in one tissue affects the physiology and pathology of other organs remains an unanswered question with therapeutic implications for chronic conditions including obesity, diabetes mellitus, atherosclerosis, and RA. Adipokines may play a role in the development of atherogenesis in patients with RA. Biologic therapies, such as TNF-α antagonists, that block proinflammatory cytokines have beneficial effects on the insulin resistance that is often observed in patients with RA.
ISSN:0962-9351
1466-1861
DOI:10.1155/2013/710928