Metabolic Syndrome in Rheumatoid Arthritis

Insulin resistance is an essential feature of the metabolic syndrome that has been linked to rheumatoid arthritis (RA). Understanding how inflammation arising in one tissue affects the physiology and pathology of other organs remains an unanswered question with therapeutic implications for chronic c...

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Published in:Mediators of Inflammation 2013-01, Vol.2013 (2013), p.402-412-245
Main Authors: Iván Ferraz-Amaro, Carlos González-Juanatey, Raquel López-Mejias, Leyre Riancho-Zarrabeitia, Miguel A. González-Gay
Format: Article
Language:English
Subjects:
Animals
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - metabolism
Cardiovascular diseases
Complications and side effects
Humans
Inflammation - metabolism
Insulin resistance
Insulin Resistance - physiology
Metabolic Syndrome - immunology
Metabolic Syndrome - metabolism
Review
Rheumatoid arthritis
Risk factors
Tumor Necrosis Factor-alpha - metabolism
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cited_by cdi_FETCH-LOGICAL-a644t-df083eaec656c1157f765f3a9c835fa4410021536a14adcc6b073c6b6abbc8c23
cites cdi_FETCH-LOGICAL-a644t-df083eaec656c1157f765f3a9c835fa4410021536a14adcc6b073c6b6abbc8c23
container_end_page 412-245
container_issue 2013
container_start_page 402
container_title Mediators of Inflammation
container_volume 2013
creator Iván Ferraz-Amaro
Carlos González-Juanatey
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description Insulin resistance is an essential feature of the metabolic syndrome that has been linked to rheumatoid arthritis (RA). Understanding how inflammation arising in one tissue affects the physiology and pathology of other organs remains an unanswered question with therapeutic implications for chronic conditions including obesity, diabetes mellitus, atherosclerosis, and RA. Adipokines may play a role in the development of atherogenesis in patients with RA. Biologic therapies, such as TNF-α antagonists, that block proinflammatory cytokines have beneficial effects on the insulin resistance that is often observed in patients with RA.
doi_str_mv 10.1155/2013/710928
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subjects Animals
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - metabolism
Cardiovascular diseases
Complications and side effects
Humans
Inflammation - metabolism
Insulin resistance
Insulin Resistance - physiology
Metabolic Syndrome - immunology
Metabolic Syndrome - metabolism
Review
Rheumatoid arthritis
Risk factors
Tumor Necrosis Factor-alpha - metabolism
title Metabolic Syndrome in Rheumatoid Arthritis
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