Epithelial apical glycosylation changes associated with thin endometrium in women with infertility - a pilot observational study

Low endometrial receptivity is one of the major factors affecting successful implantation in assisted reproductive technologies (ART). Infertile patients with thin endometrium have a significantly lower cumulative clinical pregnancy rate than patients with normal endometrium. Molecular pathophysiolo...

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Bibliographic Details
Published in:Reproductive biology and endocrinology 2021-05, Vol.19 (1), p.73-73, Article 73
Main Authors: Ziganshina, Marina M, Dolgushina, Nataliya V, Kulikova, Galina V, Fayzullina, Nafisa M, Yarotskaya, Ekaterina L, Khasbiullina, Nailia R, Abdurakhmanova, Nigora F, Asaturova, Aleksandra V, Shchegolev, Alexander I, Dovgan, Alina A, Sukhikh, Gennady T
Format: Article
Language:English
Subjects:
Adult
Analysis
Antibodies, Monoclonal - immunology
Assisted reproductive technologies (ART)
Biopsy
Carbohydrate Sequence
Carbohydrates
Cell Polarity
Cloning
Embryo Implantation
Embryo Transfer
Embryos
Endometrium
Endometrium - pathology
Epithelial cells
Epithelial Cells - metabolism
Epithelial Cells - ultrastructure
Female
Fertilization in Vitro
Glycans
Glycocalyx
Glycocalyx - chemistry
Glycoproteins
Glycosylation
Histochemistry
Histology
Humans
Implantation
In vitro fertilization
Infertility
Infertility, Female - metabolism
Infertility, Female - pathology
L-selectin
Laboratories
Lectin histochemistry
Lectins
Mannose
Medical research
Menstrual cycle
Microarray Analysis
Monoclonal antibodies
Morphogenesis
Observational studies
Oligosaccharides
Ovaries
Ovulation
Paraffin
Peritoneum
Pilot Projects
Polysaccharides
Polysaccharides - analysis
Polysaccharides - immunology
Pregnancy
Reproductive technologies
Surrogate mothers
Thin endometrium
Women
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Summary:Low endometrial receptivity is one of the major factors affecting successful implantation in assisted reproductive technologies (ART). Infertile patients with thin endometrium have a significantly lower cumulative clinical pregnancy rate than patients with normal endometrium. Molecular pathophysiology of low receptivity of thin endometrium remains understudied. We have investigated composition of glycocalyx of the apical surface of luminal and glandular epithelial cells in thin endometrium of infertile women. Thirty-two patients with tubal-peritoneal infertility undergoing in vitro fertilization (IVF) were included in the study. Endometrial samples were obtained in a natural menstrual cycle. Patients were divided into two groups: patients with normal endometrium (≥8 mm) and with thin endometrium (
ISSN:1477-7827
1477-7827
DOI:10.1186/s12958-021-00750-z