Ascorbic Acid in Colon Cancer: From the Basic to the Clinical Applications

Given the safety and potential benefits of intravenous ascorbic acid (AA) administration in cancer patients, there is merit in further exploring this therapeutic concept. In this review, we discuss the potential benefits of intravenous AA administration on colorectal cancer and we specifically focus...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-09, Vol.19 (9), p.2752
Main Authors: El Halabi, Ibrahim, Bejjany, Rachelle, Nasr, Rihab, Mukherji, Deborah, Temraz, Sally, Nassar, Farah J, El Darsa, Haidar, Shamseddine, Ali
Format: Article
Language:English
Subjects:
Acids
Angiogenesis
Animals
Ascorbic acid
Ascorbic Acid - therapeutic use
Cancer therapies
cell lines
Chemotherapy
Clinical trials
Colon
Colon cancer
Colonic Neoplasms - drug therapy
Colonic Neoplasms - genetics
Colonic Neoplasms - metabolism
Colorectal cancer
Colorectal carcinoma
CRC
Cytokines
Cytotoxicity
Disruption
Enzymes
Glycolysis
Humans
Hypoxia
Intravenous administration
Kinases
Medical research
Metabolism
Metastasis
Mutation
Pancreatic cancer
Phosphorylation
Proto-Oncogene Proteins B-raf - genetics
Review
Shutdowns
Signal Transduction - drug effects
Therapeutic applications
Transcription factors
Tumor necrosis factor-TNF
Tumors
Vitamin C
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Summary:Given the safety and potential benefits of intravenous ascorbic acid (AA) administration in cancer patients, there is merit in further exploring this therapeutic concept. In this review, we discuss the potential benefits of intravenous AA administration on colorectal cancer and we specifically focus on its effect on glycolysis in mutant and wild type . We perform a PubMed and Ovid MEDLINE search using ascorbic acid, intravenous vitamin C, mutation, mutation and colorectal cancer (CRC) as keywords. At the cellular level, colorectal cancer cells undergo a metabolic shift called the Warburg effect to allow for more glucose absorption and utilization of glycolysis. This shift also allows AA to enter which leads to a disruption in the Warburg effect and a shutdown of the downstream pathway in mutated colon cancer cells. At the clinical level, AA is associated with tumour regression in advanced disease and improved tolerability and side effects of standard therapy. Based on these findings, we conclude that further clinical trials are needed on a larger scale to examine the therapeutic benefits of AA in colon cancer.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19092752