Crack-cocaine dependence and aging: effects on working memory

To compare the working memory (WM) performance of young adult crack-cocaine dependent users, healthy older adults, and a control group of healthy young adults. A total of 77 female participants took part in this study: 26 young adult crack-cocaine dependent users (CRK), 19 healthy older adults (HO),...

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Published in:Revista brasileira de psiquiatria 2016-03, Vol.38 (1), p.58-60
Main Authors: Sanvicente-Vieira, Breno, Kommers-Molina, Júlia, De Nardi, Tatiana, Francke, Ingrid, Grassi-Oliveira, Rodrigo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
aging
Aging - physiology
Brief Communication
Case-Control Studies
Cocaine-Related Disorders - psychology
cognition
crack cocaine
Crack Cocaine - pharmacology
Female
Humans
Memory, Short-Term - drug effects
Neuropsychological Tests
PSYCHIATRY
substance use-related disorders
Working memory
Young Adult
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cited_by cdi_FETCH-LOGICAL-c510t-b46cf42fbe93ea742981280bc7af0f61af1905b7b7df5eaac259e1d7b0b2b813
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container_title Revista brasileira de psiquiatria
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creator Sanvicente-Vieira, Breno
Kommers-Molina, Júlia
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Francke, Ingrid
Grassi-Oliveira, Rodrigo
description To compare the working memory (WM) performance of young adult crack-cocaine dependent users, healthy older adults, and a control group of healthy young adults. A total of 77 female participants took part in this study: 26 young adult crack-cocaine dependent users (CRK), 19 healthy older adults (HO), and 32 healthy younger adults (HC). All participants completed the N-back verbal task. A multivariate analysis of covariance was performed. The model included education, income, and medication use as covariates. A group effect (F6,140 = 7.192, p < 0.001) was found. Post-hoc analyses showed that the performance of the CRK and HO groups was reduced compared to the HC group in two N-back conditions. No differences between the HO and CRK groups on WM performance were found. CRK participants perform similar to HO participants on a WM task, despite the well-known effects of age on WM and the young age of CRK. These data point to a possible parallel between cognitive declines associated with crack use and developmental aging.
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subjects Adolescent
Adult
Aged
aging
Aging - physiology
Brief Communication
Case-Control Studies
Cocaine-Related Disorders - psychology
cognition
crack cocaine
Crack Cocaine - pharmacology
Female
Humans
Memory, Short-Term - drug effects
Neuropsychological Tests
PSYCHIATRY
substance use-related disorders
Working memory
Young Adult
title Crack-cocaine dependence and aging: effects on working memory
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