Prognostic value of C-reactive protein-to-albumin ratio in acute pancreatitis: a systematic review and meta-analysis [version 2; peer review: 2 approved]

Background: Acute pancreatitis (AP) is a common disorder and although most of the cases are mild, the mortality risk is high when it comes to severe AP. It is therefore important to determine the severity of AP as early as possible. This review aimed to determine the prognostic value of C-reactive p...

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Bibliographic Details
Published in:F1000 research 2023, Vol.12, p.748
Main Authors: Mariadi, I Ketut, Somayana, Gde, Shalim, Christina Permata, Sindhughosa, Dwijo Anargha, Daniella, Dian, Purwanta, Made Lady Adelaida
Format: Article
Language:English
Subjects:
Acute Disease
acute pancreatitis
Albumin
Bias
C-reactive protein
C-Reactive Protein - analysis
eng
Humans
Inflammation
Meta-analysis
Mortality
Observational studies
Pancreatitis
Pancreatitis - diagnosis
Prognosis
prognostic
Proteins
Quality control
Retrospective Studies
Sensitivity analysis
Statistical analysis
Systematic Review
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Summary:Background: Acute pancreatitis (AP) is a common disorder and although most of the cases are mild, the mortality risk is high when it comes to severe AP. It is therefore important to determine the severity of AP as early as possible. This review aimed to determine the prognostic value of C-reactive protein-to-albumin ratio (CRP/alb ratio) in patients with AP. Methods: We performed a systematic search on the electronic databases PubMed, Science Direct, and Cochrane Library up to January 2023. Studies reporting CRP/alb ratio on admission and its association with severity or mortality in AP patients were included. We calculated pooled mean difference (MD) and their 95% confidence intervals (CI) using a random-effects model. Quality assessment of the included studies was appraised using a Newcastle-Ottawa scale. Results: A total of six studies comprising 2244 patients were included in this meta-analysis. Severe AP had higher CRP/alb ratio on admission than mild-moderate AP (pooled MD: 3.59; 95% CI: 2.51-4.68; p
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.134938.2