Susceptibility of Influenza A, B, C, and D Viruses to Baloxavir

Baloxavir showed broad-spectrum in vitro replication inhibition of 4 types of influenza viruses (90% effective concentration range 1.2–98.3 nmol/L); susceptibility pattern was influenza A ˃ B ˃ C ˃ D. This drug also inhibited influenza A viruses of avian and swine origin, including viruses that have...

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Bibliographic Details
Published in:Emerging infectious diseases 2019-10, Vol.25 (10), p.1969-1972
Main Authors: Mishin, Vasiliy P, Patel, Mira C, Chesnokov, Anton, De La Cruz, Juan, Nguyen, Ha T, Lollis, Lori, Hodges, Erin, Jang, Yunho, Barnes, John, Uyeki, Timothy, Davis, Charles T, Wentworth, David E, Gubareva, Larisa V
Format: Article
Language:English
Subjects:
Avian influenza
Avian influenza viruses
baloxavir
Baloxavir marboxil
Beef cattle
Dispatch
drug susceptibility
Epidemics
Expedited
Infection
Influenza
influenza viruses
Lectins
Novels
Susceptibility of Influenza A, B, C, and D Viruses to Baloxavir
Swine
Swine influenza
Zoonoses
zoonotic influenza
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Summary:Baloxavir showed broad-spectrum in vitro replication inhibition of 4 types of influenza viruses (90% effective concentration range 1.2–98.3 nmol/L); susceptibility pattern was influenza A ˃ B ˃ C ˃ D. This drug also inhibited influenza A viruses of avian and swine origin, including viruses that have pandemic potential and those resistant to neuraminidase inhibitors.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2510.190607