Atypical language localization in right temporal lobe epilepsy: An fMRI case report

• Published in: Epilepsy & behavior reports 2020-01, Vol.14, p.100364, Article 100364
• Main Authors: Gould, Layla, Wu, Adam, Tellez-Zenteno, Jose F., Neudorf, Josh, Kress, Shaylyn, Gibb, Katherine, Ekstrand, Chelsea, Dabirzadeh, Hamid, Ahmed, Syed Uzair, Borowsky, Ron
• Format: Article
• Language: English
• Subjects: Epilepsy; fMRI; Language localization; Temporal lobe epilepsy
• ISSN: 2589-9864; 2589-9864
• DOI: 10.1016/j.ebr.2020.100364

We report a 41- year-old, left-handed patient with drug-resistant right temporal lobe epilepsy (TLE). Presurgical fMRI was conducted to examine whether the patient had language functioning in the right hemisphere given that left-handedness is associated with a higher prevalence of right hemisphere dominance for language. The fMRI results revealed bilateral activation in Broca's and Wernicke's areas and activation of eloquent cortex near the region of planned resection in the right temporal lobe. Due to right temporal language-related activation, the patient underwent an awake right-sided temporal lobectomy with intraoperative language mapping. Intraoperative direct cortical stimulation (DCS) was conducted in the regions corresponding to the fMRI activation, and the patient showed language abnormalities, such as paraphasic errors, and speech arrest. The decision was made to abort the planned anterior temporal lobe procedure, and the patient instead underwent a selective amygdalohippocampectomy via the Sylvian fissure at a later date. Post-operatively the patient was seizure-free with no neurological deficits. Taken together, the results support previous findings of right hemisphere language activation in left-handed individuals, and should be considered in cases in which presurgical localization is conducted for left-hand dominant patients undergoing neurosurgical procedures. •The report evaluates evidence for the possibility of right hemisphere language activation in a left-handed right TLE patient•The results of the fMRI tasks showed bilateral speech regions, such as left and right Broca's area and Wernicke's area•The results support previous findings of right hemisphere language activation in left-handed individuals•The report discusses the value of fMRI of language tasks for presurgical planning in epilepsy cases•Report highlights how fMRI findings can alter surgical strategy and how intraoperative brain mapping validates these findings