Numerical simulation and in vitro examination of the flow behaviour within coronary stents

This paper discusses the influence of different design parameters of stents by mathematical flow simulations and flow measurements using micro-particle image velocimetry (micro-PIV). A stent strut may cause recirculation areas, which are considered to be the source of thrombosis and the process of i...

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Bibliographic Details
Published in:Current directions in biomedical engineering 2019-09, Vol.5 (1), p.541-544
Main Authors: Melzer, Helena-Sophie, Ahrens, Ralf, Guber, Andreas E., Dohse, Jakob
Format: Article
Language:English
Subjects:
In-Stent-Restenosis
mathematical flow simulations
micro-PIV
PDMS
Stents
Thrombosis
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Summary:This paper discusses the influence of different design parameters of stents by mathematical flow simulations and flow measurements using micro-particle image velocimetry (micro-PIV). A stent strut may cause recirculation areas, which are considered to be the source of thrombosis and the process of in-stent restenosis. The simulations showed that a reduced strut height and a chamfering of the struts reduce these recirculation zones. The numerically determined results were compared with experimental investigations. For this purpose metallic stent structures were transferred into transparent channel systems made of PDMS. The experimental investigations confirm the results of numerical simulations.
ISSN:2364-5504
2364-5504
DOI:10.1515/cdbme-2019-0136