Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease

• Published in: BMC cardiovascular disorders 2021-04, Vol.21 (1), p.162-162, Article 162
• Main Authors: Gallo, Widet, Ottosson, Filip, Kennbäck, Cecilia, Jujic, Amra, Esguerra, Jonathan Lou S, Eliasson, Lena, Melander, Olle
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; Arteriosclerosis; Atherosclerosis; Basic Medicine; Biomarkers - blood; Cancer; Cardiac and Cardiovascular Systems; Cardiometabolic disease; Cardiometabolic Risk Factors; Cardiovascular disease; Cardiovascular diseases; Carotid arteries; Carotid Artery Diseases - blood; Carotid Artery Diseases - epidemiology; Carotid Artery Diseases - genetics; Cell and Molecular Biology; Cell- och molekylärbiologi; Clinical Medicine; Coronary artery; Coronary Artery Disease - blood; Coronary Artery Disease - epidemiology; Coronary Artery Disease - genetics; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Diabetes Mellitus - blood; Diabetes Mellitus - epidemiology; Diabetes Mellitus - genetics; Fasting; Female; Gene expression; Genetic aspects; Genetic crosses; Glucose; Health aspects; Heart diseases; High density lipoprotein; Humans; Incidence; Insulin resistance; Kardiologi; Klinisk medicin; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Metabolic diseases; Metabolic Syndrome - blood; Metabolic Syndrome - epidemiology; Metabolic Syndrome - genetics; Metabolic Syndrome - prevention & control; MicroRNA; MicroRNAs; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; MiR-483-5p; Plaques; Population; Population studies; Prevention; Prospective Studies; Risk Assessment; Risk factors; Serum levels; Sweden; Time Factors; Triglycerides; Ultrasonic imaging; Ultrasound; Values
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-021-01964-0

Alterations in levels of circulating micro-RNAs might reflect within organ signaling or subclinical tissue injury that is linked to risk of diabetes and cardiovascular risk. We previously found that serum levels of miR-483-5p is correlated with cardiometabolic risk factors and incidence of cardiometabolic disease in a case-control sample from the populations-based Malmö Diet and Cancer Study Cardiovascular Cohort (MDC-CC). We here aimed at replicating these findings and to test for association with carotid atherosclerosis. We measured miR-483-5p in fasting serum of 1223 healthy subjects from the baseline examination of the population-based, prospective cohort study Malmö Offspring Study (MOS) and correlated miR-483-5p to cardiometabolic risk factors and to incidence of diabetes mellitus and coronary artery disease (CAD) during 3.7 (± 1.3) years of follow-up using logistic regression. In both MOS and MDC-CC we related mir-483-5p to carotid atherosclerosis measured with ultrasound. In cross-sectional analysis miR-483-5p was correlated with BMI, waist circumference, HDL, and sex. After adjustment for age and sex, the association remained significant for all risk factors except for HDL. Logistic regression analysis showed significant associations between miR-483-5p and new-onset diabetes (OR = 1.94, 95% CI 1.06-3.56, p = 0.032) and cardiovascular disease (OR = 1.99, 95% CI 1.06-3.75, p = 0.033) during 3.7 (± 1.3) years of follow-up. Furthermore, miR-483-5p was significantly related with maximum intima-media thickness of the carotid bulb in MDC-CC (p = 0.001), but not in MOS, whereas it was associated with increasing number of plaques in MOS (p = 0.007). miR-483-5p is related to an unfavorable cardiometabolic risk factor profile and predicts diabetes and CAD, possibly through an effect on atherosclerosis. Our results encourage further studies of possible underlying mechanisms and means of modifying miR-483-5p as a possible interventional target in prevention of cardiometabolic disease.